Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study. Issue 1 (14th February 2022)

• Record Type: Journal Article
• Authors: Reyes, Luis Felipe; Murthy, Srinivas; Garcia-Gallo, Esteban; Irvine, Mike; Merson, Laura; Martin-Loeches, Ignacio; Rello, Jordi; Taccone, Fabio S.; Fowler, Robert A.; Docherty, Annemarie B.; Kartsonaki, Christiana; Aragao, Irene; Barrett, Peter W.; Beane, Abigail; Burrell, Aidan; Cheng, Matthew Pellan; Christian, Michael D.; Cidade, Jose Pedro; Citarella, Barbara Wanjiru; Donnelly, Christl A.; Fernandes, Susana M.; French, Craig; Haniffa, Rashan; Harrison, Ewen M.; Ho, Antonia Ying Wai; Joseph, Mark; Khan, Irfan; Kho, Michelle E.; Kildal, Anders Benjamin; Kutsogiannis, Demetrios; Lamontagne, François; Lee, Todd C.; Bassi, Gianluigi Li; Lopez Revilla, Jose Wagner; Marquis, Catherine; Millar, Jonathan; Neto, Raul; Nichol, Alistair; Parke, Rachael; Pereira, Rui; Poli, Sergio; Povoa, Pedro; Ramanathan, Kollengode; Rewa, Oleksa; Riera, Jordi; Shrapnel, Sally; Silva, Maria Joao; Udy, Andrew; Uyeki, Timothy; Webb, Steve A.; Wils, Evert-Jan; Rojek, Amanda; Olliaro, Piero L.;
• Other Names: Reyes Luis Felipe author non-byline.; Murthy Srinivas author non-byline.; Garcia-Gallo Esteban author non-byline.; Irvine Mike author non-byline.; Merson Laura author non-byline.; Martin-Loeches Ignacio author non-byline.; Rello Jordi author non-byline.; Taccone Fabio S. author non-byline.; Webb Steve A. author non-byline.; Fowler Robert A. author non-byline.; Docherty Annemarie B author non-byline.; Donnelly Christl A. author non-byline.; Kartsonaki Christiana author non-byline.; Aragao Irene author non-byline.; Barrett Peter W. author non-byline.; Beane Abigail author non-byline.; Broadley Tessa author non-byline.; Cheng Matthew Pellan author non-byline.; Christian Michael D. author non-byline.; Cidade Jose Pedro author non-byline.; Citarella Barbara Wanjiru author non-byline.; Fernandes Susana author non-byline.; Haniffa Rashan author non-byline.; Harrison Ewen M. author non-byline.; Ho Antonia Ying Wai author non-byline.; Joseph Mark author non-byline.; Khan Irfan author non-byline.; Kho Michelle E author non-byline.; Kildal Anders Benjamin author non-byline.; Kutsogiannis Demetrios author non-byline.; Lamontagne François author non-byline.; Lee Todd C. author non-byline.; Li Bassi Gianluigi author non-byline.; Lopez Revilla Jose Wagner author non-byline.; Marquis Catherine author non-byline.; Millar Jonathan author non-byline.; Neto Raul author non-byline.; Nichol Alistair author non-byline.; Olliaro Piero L. author non-byline.; Parke Rachael author non-byline.; Pereira Rui author non-byline.; Poli Sergio author non-byline.; Povoa Pedro author non-byline.; Ramanathan Kollengode author non-byline.; Rello Jordi author non-byline.; Rewa Oleksa author non-byline.; Riera Jordi author non-byline.; Rojek Amanda author non-byline.; Shrapnel Sally author non-byline.; Silva Maria Joao author non-byline.; Trapani Tony author non-byline.; Udy Andrew author non-byline.; Uyeki Timothy author non-byline.; Wils Evert-Jan author non-byline.; Reyes Luis Felipe author non-byline.; Garcia-Gallo Esteban author non-byline.; Murthy Srinivas author non-byline.; Irvine Mike author non-byline.; Merson Laura author non-byline.; Reyes Luis Felipe author non-byline.; Garcia-Gallo Esteban author non-byline.; Irvine Mike author non-byline.; Citarella Barbara Wanjiru author non-byline.; Kelly Sadie author non-byline.; Kennon Kalynn author non-byline.; Lee James author non-byline.; Merson Laura author non-byline.; Plotkin Daniel author non-byline.; Smith Sue author non-byline.; Strudwick Samantha author non-byline.; Citarella Barbara Wanjiru author non-byline.; Reyes Luis Felipe author non-byline.; Garcia-Gallo Esteban author non-byline.; Murthy Srinivas author non-byline.; Irvine Mike author non-byline.; Merson Laura author non-byline.; Reyes Luis Felipe author non-byline.; Garcia-Gallo Esteban author non-byline.; Irvine Mike author non-byline.; Abdukahil Sheryl Ann author non-byline.; Abe Ryuzo author non-byline.; Abel Laurent author non-byline.; Absil Lara author non-byline.; Acharya Subhash author non-byline.; Acker Andrew author non-byline.; Adachi Shingo author non-byline.; Adam Elisabeth author non-byline.; Adrião Diana author non-byline.; Ageel Saleh Al author non-byline.; Ain Quratul author non-byline.; Ainscough Kate author non-byline.; Ait Hssain Ali author non-byline.; Ait Tamlihat Younes author non-byline.; Akimoto Takako author non-byline.; Akmal Ernita author non-byline.; Al Qasim Eman author non-byline.; Alalqam Razi author non-byline.; Alam Tanvir author non-byline.; Al-dabbous Tala author non-byline.; Alegre Cynthia author non-byline.; Alex Beatrice author non-byline.; Alexandre Kévin author non-byline.; Al-Fares Abdulrahman author non-byline.; Alfoudri Huda author non-byline.; Ali Shah Naseem author non-byline.; Alidjnou Kazali Enagnon author non-byline.; Aliudin Jeffrey author non-byline.; Allavena Clotilde author non-byline.; Alves João Melo author non-byline.; Alves João author non-byline.; Alves Rita author non-byline.; Amaral Maria author non-byline.; Ampaw Phoebe author non-byline.; Andini Roberto author non-byline.; Andrejak Claire author non-byline.; Angheben Andrea author non-byline.; Angoulvant François author non-byline.; Ansart Séverine author non-byline.; Antonelli Massimo author non-byline.; Antunes de Brito Carlos Alexandre author non-byline.; Apriyana Ardiyan author non-byline.; Arabi Yaseen author non-byline.; Aragao Irene author non-byline.; Arancibia Francisco author non-byline.; Arcadipane Antonio author non-byline.; Archambault Patrick author non-byline.; Arenz Lukas author non-byline.; Arlet Jean-Benoît author non-byline.; Arnold-Day Christel author non-byline.; Arora Lovkesh author non-byline.; Arora Rakesh author non-byline.; Artaud-Macari Elise author non-byline.; Aryal Diptesh author non-byline.; Asensio Angel author non-byline.; Assie Jean Baptiste author non-byline.; Atique Anika author non-byline.; Attanyake A.M. Udara Lakshan author non-byline.; Auchabie Johann author non-byline.; Aumaitre Hugues author non-byline.; Azemar Laurène author non-byline.; Azoulay Cecile author non-byline.; Bach Benjamin author non-byline.; Bachelet Delphine author non-byline.; Badr Claudine author non-byline.; Baillie J. Kenneth author non-byline.; Bak Erica author non-byline.; Bakakos Agamemnon author non-byline.; Bal Andriy author non-byline.; Bani-Sadr Firouzé author non-byline.; Barrasa Helena author non-byline.; Barbalho Renata author non-byline.; Barclay Wendy S. author non-byline.; Barnikel Michaela author non-byline.; Barrigoto Cleide author non-byline.; Bartoli Marie author non-byline.; Bartone Cheryl author non-byline.; Baruch Joaquín author non-byline.; Basmaci Romain author non-byline.; Bauer Jules author non-byline.; Bautista Diego author non-byline.; Beane Abigail author non-byline.; Behilill Sylvie author non-byline.; Beljantsev Aleksandr author non-byline.; Bellemare David author non-byline.; Beltrame Anna author non-byline.; Beluze Marine author non-byline.; Benech Nicolas author non-byline.; Benkerrou Dehbia author non-byline.; Bennett Suzanne author non-byline.; Bento Luís author non-byline.; Berdal Jan-Erik author non-byline.; Bergeaud Delphine author non-byline.; Bertolino Lorenzo author non-byline.; Bessis Simon author non-byline.; Bevilcaqua Sybille author non-byline.; Bhatt Amar author non-byline.; Bhavsar Krishna author non-byline.; Bianchi Isabella author non-byline.; Bianco Claudia author non-byline.; Bikram Singh Moirangthem author non-byline.; Bin Humaid Felwa author non-byline.; Biston Patrick author non-byline.; Bitker Laurent author non-byline.; Blanco-Schweizer Pablo author non-byline.; Blandino Ortiz Aaron author non-byline.; Blier Catherine author non-byline.; Blot Mathieu author non-byline.; Boccia Filomena author non-byline.; Bodenes Laetitia author non-byline.; Bogaert Debby author non-byline.; Bolze Pierre-Adrien author non-byline.; Bompart François author non-byline.; Borges Diogo author non-byline.; Borie Raphaël author non-byline.; Bosse Hans Martin author non-byline.; Botelho-Nevers Elisabeth author non-byline.; Bouadma Lila author non-byline.; Bouchaud Olivier author non-byline.; Bouchez Sabelline author non-byline.; Bouhmani Dounia author non-byline.; Bouhour Damien author non-byline.; Bouiller Kévin author non-byline.; Bouillet Laurence author non-byline.; Bouisse Camile author non-byline.; Boureau Anne-Sophie author non-byline.; Bouscambert Maude author non-byline.; Bouziotis Jason author non-byline.; Boxma Bianca author non-byline.; Boyer-Besseyre Marielle author non-byline.; Boylan Maria author non-byline.; Bozza Fernando Augusto author non-byline.; Brack Matthew author non-byline.; Braga Cynthia author non-byline.; Brandenburger Timo author non-byline.; Brás Monteiro Filipa author non-byline.; Brazzi Luca author non-byline.; Breen Dorothy author non-byline.; Breen Patrick author non-byline.; Brickell Kathy author non-byline.; Broadley Tessa author non-byline.; Browne Alex author non-byline.; Brozzi Nicolas author non-byline.; Buchtele Nina author non-byline.; Buesaquillo Christian author non-byline.; Buisson Marielle author non-byline.; Burhan Erlina author non-byline.; Burrell Aidan author non-byline.; Bustos Ingrid G. author non-byline.; Cabie André author non-byline.; Cabral Susana author non-byline.; Caceres Eder author non-byline.; Cadoz Cyril author non-byline.; Calligy Kate author non-byline.; Calvache Jose Andres author non-byline.; Camões João author non-byline.; Campana Valentine author non-byline.; Campbell Paul author non-byline.; Canepa Cecilia author non-byline.; Cantero Mireia author non-byline.; Caraux-Paz Pauline author non-byline.; Cárcel Sheila author non-byline.; Cardellino Chiara author non-byline.; Cardoso Filipa author non-byline.; Cardoso Filipe author non-byline.; Cardoso Nelson author non-byline.; Cardoso Sofia author non-byline.; Carelli Simone author non-byline.; Carlier Nicolas author non-byline.; Carney Gayle author non-byline.; Carpenter Chloe author non-byline.; Carret Marie-Christine author non-byline.; Carrier François Martin author non-byline.; Carson Gail author non-byline.; Casanova Maire-Laure author non-byline.; Cascão Mariana author non-byline.; Casimiro José author non-byline.; Cassandra Bailey author non-byline.; Castañeda Silvia author non-byline.; Castanheira Nidyanara author non-byline.; Castor-Alexandre Guylaine author non-byline.; Castrillón Henry author non-byline.; Castro Ivo author non-byline.; Catarino Ana author non-byline.; Catherine François-Xavier author non-byline.; Cavalin Roberta author non-byline.; Cavayas Alexandros author non-byline.; Ceccato Adrian author non-byline.; Cervantes-Gonzalez Minerva author non-byline.; Chair Anissa author non-byline.; Chakveatze Catherine author non-byline.; Chan Adrienne author non-byline.; Chand Meera author non-byline.; Chantalat Auger Christelle author non-byline.; Chapplain Jean-Marc author non-byline.; Chaudary Mobin author non-byline.; Chen Anjellica author non-byline.; Chen Yih-Sharng author non-byline.; Cheng Matthew Pellan author non-byline.; Cheret Antoine author non-byline.; Chiarabini Thibault author non-byline.; Chica Julian author non-byline.; Chirouze Catherine author non-byline.; Chiumello Davide author non-byline.; Cho Hwa Jin author non-byline.; Cho Sung Min author non-byline.; Cholley Bernard author non-byline.; Chopin Marie-Charlotte author non-byline.; Cidade Jose Pedro author non-byline.; Citarella Barbara Wanjiru author non-byline.; Ciullo Anna author non-byline.; Clarke Jennifer author non-byline.; Clohisey Sara author non-byline.; Coca Necsoi author non-byline.; Codan Cassidy author non-byline.; Cody Caitriona author non-byline.; Coelho Alexandra author non-byline.; Colin Gwenhaël author non-byline.; Collins Michael author non-byline.; Colombo Sebastiano Maria author non-byline.; Combs Pamela author non-byline.; Connor Marie author non-byline.; Conrad Anne author non-byline.; Contreras Sofía author non-byline.; Cooke Graham S. author non-byline.; Copland Mary author non-byline.; Cordel Hugues author non-byline.; Corley Amanda author non-byline.; Cormican Sarah author non-byline.; Cornelis Sabine author non-byline.; Corpuz Arianne Joy author non-byline.; Corvaisier Grégory author non-byline.; Couffignal Camille author non-byline.; Couffin-Cadiergues Sandrine author non-byline.; Courtois Roxane author non-byline.; Cousse Stéphanie author non-byline.; Croonen Sabine author non-byline.; Crowl Gloria author non-byline.; Crump Jonathan author non-byline.; Cruz Claudina author non-byline.; Csete Marc author non-byline.; Cullen Caroline author non-byline.; Cummings Matthew author non-byline.; Curley Gerard author non-byline.; Curlier Elodie author non-byline.; Custodio Paula author non-byline.; da Silva Filipe Ana author non-byline.; Da Silveira Charlene author non-byline.; Dabaliz Al-Awwab author non-byline.; Dagens Andrew author non-byline.; Dalton Heidi author non-byline.; Dalton Jo author non-byline.; Daneman Nick author non-byline.; Dankwa Emmanuelle author non-byline.; Dantas Jorge author non-byline.; D'Aragon Frédérick author non-byline.; de Mendoza Diego author non-byline.; De Montmollin Etienne author non-byline.; de Oliveira França Rafael Freitas author non-byline.; De Pablo Raúl author non-byline.; de Pinho Oliveira Ana Isabel author non-byline.; De Rosa Rosanna author non-byline.; de Silva Thushan author non-byline.; De Vries Peter author non-byline.; Deacon Jillian author non-byline.; Dean David author non-byline.; Debard Alexa author non-byline.; Debray Marie-Pierre author non-byline.; DeCastro Nathalie author non-byline.; Dechert William author non-byline.; Deconninck Lauren author non-byline.; Decours Romain author non-byline.; Delacroix Isabelle author non-byline.; Delfos Nathalie M. author non-byline.; Deligiannis Ionna author non-byline.; Dell'Amore Andrea author non-byline.; Delmas Christelle author non-byline.; Delobel Pierre author non-byline.; Denis Emmanuelle author non-byline.; Deplanque Dominique author non-byline.; Depuydt Pieter author non-byline.; Desai Mehul author non-byline.; Descamps Diane author non-byline.; Desvallée Mathilde author non-byline.; Dewayanti Santi author non-byline.; Diallo Alpha author non-byline.; Diamantis Sylvain author non-byline.; Diaz Rodrigo author non-byline.; Diaz Juan Jose author non-byline.; Diaz Priscila author non-byline.; Didier Kévin author non-byline.; Diehl Jean-Luc author non-byline.; Dieperink Wim author non-byline.; Dimet Jérôme author non-byline.; Dinot Vincent author non-byline.; Diop Fara author non-byline.; Diouf Alphonsine author non-byline.; Dishon Yael author non-byline.; Djossou Félix author non-byline.; Docherty Annemarie B. author non-byline.; Dondorp Arjen M author non-byline.; Donnelly Christl A. author non-byline.; Donnelly Maria author non-byline.; Donohue Chloe author non-byline.; Dorival Céline author non-byline.; D'Ortenzio Eric author non-byline.; Douglas James Joshua author non-byline.; Douma Renee author non-byline.; Dournon Nathalie author non-byline.; Downer Triona author non-byline.; Downing Mark author non-byline.; Drake Tom author non-byline.; Driscoll Aoife author non-byline.; Duarte Fonseca Claudio author non-byline.; Dubos François author non-byline.; Duculan Toni author non-byline.; Dudman Susanne author non-byline.; Dunning Jake author non-byline.; 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Evers Mirjam author non-byline.; Fabre Isabelle author non-byline.; Faheem Amna author non-byline.; Fahy Arabella author non-byline.; Fairfield Cameron J. author non-byline.; Faria Pedro author non-byline.; Farooq Ahmed author non-byline.; Farshait Nataly author non-byline.; Fatoni Arie Zainul author non-byline.; Faure Karine author non-byline.; Favory Raphaël author non-byline.; Fayed Mohamed author non-byline.; Feely Niamh author non-byline.; Fernandes Jorge author non-byline.; Fernandes Marília author non-byline.; Fernandes Susana author non-byline.; Ferrand Devouge Eglantine author non-byline.; Ferrão Joana author non-byline.; Ferraz Mário author non-byline.; Ferrer-Roca Ricard author non-byline.; Ferriere Nicolas author non-byline.; Figueiredo-Mello Claudia author non-byline.; Fiorda Juan author non-byline.; Flament Thomas author non-byline.; Flateau Clara author non-byline.; Fletcher Tom author non-byline.; Florio Letizia Lucia author non-byline.; Flynn Brigid author non-byline.; 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Goujard Cécile author non-byline.; Goulenok Tiphaine author non-byline.; Grable Margarite author non-byline.; Graf Jeronimo author non-byline.; Grandin Edward Wilson author non-byline.; Grasselli Giacomo author non-byline.; Grazioli Lorenzo author non-byline.; Green Christopher A. author non-byline.; Greenhalf William author non-byline.; Grieco Domenico Luca author non-byline.; Griffee Matthew author non-byline.; Griffiths Fiona author non-byline.; Grigoras Ioana author non-byline.; Groenendijk Albert author non-byline.; Gruner Heidi author non-byline.; Gu Yusing author non-byline.; Guedj Jérémie author non-byline.; Guellec Dewi author non-byline.; Guerguerian Anne-Marie author non-byline.; Guerreiro Daniela author non-byline.; Guery Romain author non-byline.; Guillaumot Anne author non-byline.; Guilleminault Laurent author non-byline.; Guimard Thomas author non-byline.; Haber Daniel author non-byline.; Hadri Nadir author non-byline.; Hakak Sheeba author non-byline.; Hall Matthew author non-byline.; 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Kelly Sadie author non-byline.; Kennedy Ryan author non-byline.; Kennon Kalynn author non-byline.; Kerroumi Younes author non-byline.; Kestelyn Evelyne author non-byline.; Khalid Imrana author non-byline.; Khalil Antoine author non-byline.; Khan Coralie author non-byline.; Khan Irfan author non-byline.; Khanal Sushil author non-byline.; Kho Michelle E author non-byline.; Khoo Saye author non-byline.; Khoso Nasir author non-byline.; Kida Yuri author non-byline.; Kiiza Peter author non-byline.; Kildal Anders Benjamin author non-byline.; Kim Jae Burm author non-byline.; Kimmoun Antoine author non-byline.; Kindgen-Milles Detlef author non-byline.; Kitamura Nobuya author non-byline.; Klenerman Paul author non-byline.; Kloumann Bekken Gry author non-byline.; Knight Stephen author non-byline.; Kodippily Chamira author non-byline.; Kohns Vasconcelos Malte author non-byline.; Koirala Sabin author non-byline.; Komatsu Mamoru author non-byline.; Kosgei Caroline author non-byline.; Kpangon Arsène author non-byline.; 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• Is Part Of: ERJ open research. Volume 8:Issue 1(2022)
• Publication Date: 2022-02-14
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; Respiration; Respiratory organs -- Diseases; Respiratory organs -- Diseases -- Treatment; Respiratory Tract Diseases; Electronic journals; Fulltext; Internet Resources; Periodicals; Periodical; 616.2005
• DOI: 10.1183/23120541.00552-2021
• Languages: English
• ISSNs: 2312-0541

Abstract

Due to the large number of patients with severe coronavirus disease 2019 (COVID-19), many were treated outside the traditional walls of the intensive care unit (ICU), and in many cases, by personnel who were not trained in critical care. The clinical characteristics and the relative impact of caring for severe COVID-19 patients outside the ICU is unknown. This was a multinational, multicentre, prospective cohort study embedded in the International Severe Acute Respiratory and Emerging Infection Consortium World Health Organization COVID-19 platform. Severe COVID-19 patients were identified as those admitted to an ICU and/or those treated with one of the following treatments: invasive or noninvasive mechanical ventilation, high-flow nasal cannula, inotropes or vasopressors. A logistic generalised additive model was used to compare clinical outcomes among patients admitted or not to the ICU. A total of 40 440 patients from 43 countries and six continents were included in this analysis. Severe COVID-19 patients were frequently male (62.9%), older adults (median (interquartile range (IQR), 67 (55–78) years), and with at least one comorbidity (63.2%). The overall median (IQR) length of hospital stay was 10 (5–19) days and was longer in patients admitted to an ICU than in those who were cared for outside the ICU (12 (6–23) days versus 8 (4–15) days, p<0.0001). The 28-day fatality ratio was lower in ICU-admitted patients (30.7% (5797 out of 18 831) versus 39.0% (7532 out of 19 295), p<0.0001). Patients admitted to an ICU had a significantly lower probability of death than those who were not (adjusted OR 0.70, 95% CI 0.65–0.75; p<0.0001). Patients with severe COVID-19 admitted to an ICU had significantly lower 28-day fatality ratio than those cared for outside an ICU. Countries and hospitals need to identify strategies to increase their ICU capacity ( i.e. trained personnel, ICU beds and monitoring systems) to treat patients presenting to the hospital with severe #COVID19 rather than provide such care outside of the ICU https://bit.ly/3xh9A6M