A post hoc analysis on the effects of a probiotic mixture on asthma exacerbation frequency in schoolchildren. Issue 2 (9th May 2022)

• Record Type: Journal Article
• Authors: Drago, Lorenzo; Cioffi, Luigi; Giuliano, Maria; Pane, Marco; Ciprandi, Giorgio
• Is Part Of: ERJ open research. Volume 8:Issue 2(2022)
• Publication Date: 2022-05-09
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; Respiration; Respiratory organs -- Diseases; Respiratory organs -- Diseases -- Treatment; Respiratory Tract Diseases; Electronic journals; Fulltext; Internet Resources; Periodicals; Periodical; 616.2005
• DOI: 10.1183/23120541.00020-2022
• Languages: English
• ISSNs: 2312-0541

Abstract

Asthma is usually characterised by chronic airway inflammation [1]. Furthermore, respiratory infections frequently precede asthma exacerbations in children, mainly in allergic subjects [2–4]. As a result, dampening inflammation and preventing respiratory infections are essential in the therapeutical strategy. It has been underscored by the pathogenic relevance of dysbiosis, as it has been evidenced that the children with asthma present dysbiosis of the gut and lung microbiome [5]. The dysbiosis affects the immune response and, consequently, induces airways inflammation, and airflow limitation [6]. These events constituted the premise of using probiotics to modulate the immune response to restore the microbiota and immune balance [7]. Probiotics are defined as "live microorganisms which confer a beneficial effect on the host", according to the World Health Organization [8]. The present randomised, placebo-controlled, double-blind study showed that a probiotic mixture significantly reduced the number of asthma exacerbations in schoolchildren https://bit.ly/382LYKV