Dysglycaemia among tuberculosis patients without known diabetes in a low-endemic setting. Issue 2 (11th April 2022)

• Record Type: Journal Article
• Authors: Jørgensen, Anja; Lorentsson, Hans Johan Niklas; Grundtvig Huber, Franziska; Graff Jensen, Sidse; Bjorn-Mortensen, Karen; Ravn, Pernille
• Is Part Of: ERJ open research. Volume 8:Issue 2(2022)
• Publication Date: 2022-04-11
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; Respiration; Respiratory organs -- Diseases; Respiratory organs -- Diseases -- Treatment; Respiratory Tract Diseases; Electronic journals; Fulltext; Internet Resources; Periodicals; Periodical; 616.2005
• DOI: 10.1183/23120541.00629-2021
• Languages: English
• ISSNs: 2312-0541

Abstract

There is increasing evidence that diabetes mellitus is an important risk factor for tuberculosis (TB) and might affect TB-disease presentation as well as treatment response [1]. The hypothesis is that an impaired immune response in persons with diabetes mellitus facilitates infection with Mycobacterium tuberculosis and/or progression to TB, and reversely, M. tuberculosis infection may affect glycaemic control [2, 3]. Although the exact causality is unknown, this association between TB and diabetes mellitus is ominous, as the explosive rise in diabetes mellitus worldwide witnessed over the last decades could potentially counteract the positive effect of TB control efforts. With a high prevalence of dysglycaemia (29.1%) among tuberculosis patients without previously known diabetes, this study highlights the importance of comanagement of tuberculosis and diabetes, even in a low-endemic setting https://bit.ly/3Gj0gmN