Sporadic pemphigus foliaceus and class II human leucocyte antigen allele associations in the white British and Indo‐Asian populations in the UK. (1st April 2019)

• Record Type: Journal Article
• Authors: Saha, M.; Harman, K.; Mortimer, N. J.; Binda, V.; Black, M. M.; Kondeatis, E.; Vaughan, R.; Groves, R. W.
• Is Part Of: Clinical and experimental dermatology. Volume 44:Number 3(2019)
• Page Start: 290
• Page End: 294
• Publication Date: 2019-04-01
• Subjects: Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/ced.13774
• Languages: English
• ISSNs: 0307-6938

Abstract

Summary: Background: Pemphigus foliaceus (PF) has both genetic and environmental susceptibility factors. Current data on human leucocyte antigen (HLA) in patients with sporadic PF are limited. Aim: To better define the distribution of HLA alleles in patients with PF in the UK. Methods: We recruited 36 patients [26 of white British (WB) descent, 10 of Indo‐Asian (IA) descent] with PF who were living in the UK and 159 ethnically matched normal controls, and analysed their class II HLA DRB1 and DQB1 allele distribution. Results: There was an increased frequency of DRB1*1404 in association with DQB1*0503 in IA patients with PF. The DRB1*04 allele group as a whole had an increased frequency ( P < 0.001) in the WB patient group compared with controls. The alleles contributing to this significance were DRB1*0401 ( P = 0.03) and DRB1*0404 ( P < 0.01). Conclusion: This is the largest HLA association study in sporadic PF from the UK to date. There appears to be a difference in PF susceptibility alleles between WB and IA patients, highlighting the importance of racial variation in genetic susceptibility to disease development.