Amyloidosis in hidradenitis suppurativa: a cross‐sectional study and review of the literature. (1st July 2020)

• Record Type: Journal Article
• Authors: Kridin, K.; Amber, K. T.; Comaneshter, D.; Cohen, A. D.
• Is Part Of: Clinical and experimental dermatology. Volume 45:Number 5(2020)
• Page Start: 565
• Page End: 571
• Publication Date: 2020-07-01
• Subjects: Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/ced.14186
• Languages: English
• ISSNs: 0307-6938

Abstract

Summary: Background: Coexistence of hidradenitis suppurativa (HS) and amyloidosis has been anecdotally described, but the association between these conditions is yet to be firmly established. Aim: To study the association between HS and amyloidosis using a large‐scale computerized database, and to perform a literature review to characterize all reported patients with coexistent HS and amyloidosis. Methods: A cross‐sectional study was conducted comparing the prevalence of amyloidosis among patients with HS and age‐, sex‐ and ethnicity‐matched healthy controls (HCs). Additionally, a review of literature was performed to summarize all reported cases with a dual diagnosis of both conditions. Results: In total, 4417 patients with HS and 22 085 controls were included in the study. The prevalence of amyloidosis was increased in patients with HS compared with the HC group [ n = 7 (0.2%) vs. n = 2 (0.0%), respectively; OR = 17.5; 95% CI 3.6–84.4; P < 0.001]. In a multivariate analysis, HS was still associated with amyloidosis (OR = 11.2; 95% CI 1.3–94.5; P = 0.03). The literature review identified nine patients who developed amyloidosis during the course of HS, with 44.4% eventually having renal failure. ‬Favourable outcomes were reported in patients managed by tumour necrosis factor (TNF)‐α inhibitors. Conclusion: This study establishes the association between HS and amyloidosis. Screening for amyloidosis may be considered in patients with HS with a relevant clinical picture, mainly proteinuria. TNF‐α inhibitors may be preferred in patients with a dual diagnosis of these conditions.