Pediatric Tuberculosis Diagnostics: Present and Future. (31st October 2022)

• Record Type: Journal Article
• Authors: Basile, Francesca Wanda; Nabeta, Pamela; Ruhwald, Morten; Song, Rinn
• Is Part Of: Journal of the Pediatric Infectious Diseases Society. Volume 11(2022)Supplement 3
• Page Start: S85
• Page End: S93
• Publication Date: 2022-10-31
• Subjects: children -- diagnostics -- host-based -- molecular -- pipeline -- tuberculosis; Communicable diseases in children -- Periodicals; Children -- Diseases -- Periodicals; 618.929
• DOI: 10.1093/jpids/piac082
• Languages: English
• ISSNs: 2048-7193

Abstract

Abstract: The current diagnostic abilities for the detection of pediatric tuberculosis are suboptimal. Multiple factors contribute to the under-diagnosis of intrathoracic tuberculosis in children, namely the absence of pathognomonic features of the disease, low bacillary loads in respiratory specimens, challenges in sample collection, and inadequate access to diagnostic tools in high-burden settings. Nonetheless, the 2020s have witnessed encouraging progress in the area of novel diagnostics. Recent WHO-endorsed rapid molecular assays hold promise for use in service decentralization strategies, and new policy recommendations include stools as an alternative, child-friendly specimen for testing with the GeneXpert assay. The pipeline of promising assays in mid/late-stage development is expanding, and novel pediatric candidate biomarkers based on the host immune response are being identified for use in diagnostic and triage tests. For a new test to meet the pediatric target product profiles prioritized by the WHO, it is key that the peculiarities and needs of the hard-to-reach pediatric population are considered in the early planning phases of discovery, validation, and implementation studies.