Development of γδ T cells in the thymus – A human perspective. (November 2022)

• Record Type: Journal Article
• Authors: Boehme, Lena; Roels, Juliette; Taghon, Tom
• Is Part Of: Seminars in immunology. Volume 61/64(2022)
• Publication Date: 2022-11
• Subjects: γδ T cells -- T cell development -- Lineage commitment -- Human -- Thymocyte -- Thymus; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Immunity -- Periodicals; Immunologie -- Périodiques; Electronic journals; 616.079
• DOI: 10.1016/j.smim.2022.101662
• Languages: English
• ISSNs: 1044-5323

Abstract

Abstract: γδ T cells are increasingly emerging as crucial immune regulators that can take on innate and adaptive roles in the defence against pathogens. Although they arise within the thymus from the same hematopoietic precursors as conventional αβ T cells, the development of γδ T cells is less well understood. In this review, we focus on summarising the current state of knowledge about the cellular and molecular processes involved in the generation of γδ T cells in human.