Immunological basis of virus‐host interaction in COVID‐19. (24th November 2020)

• Record Type: Journal Article
• Authors: La Torre, Francesco; Leonardi, Lucia; Giardino, Giuliana; Volpi, Stefano; Federici, Silvia; Soresina, Annarosa; Cancrini, Caterina; Lougaris, Vassilios; Castagnoli, Riccardo; Corrente, Stefania; Cardinale, Fabio
• Editors: Marseglia, Gian Luigi
• Other Names: Marseglia Gian Luigi guestEditor.
• Is Part Of: Pediatric allergy and immunology. Volume 31(2020)Supplement 26
• Page Start: 75
• Page End: 78
• Publication Date: 2020-11-24
• Subjects: children -- COVID‐19 -- cytokine storm -- immunopathogenesis -- Kawasaki disease; Allergy in children -- Periodicals; Immunologic diseases in children -- Periodicals; 617
• DOI: 10.1111/pai.13363
• Languages: English
• ISSNs: 0905-6157

Abstract

Abstract: COVID‐19 is a complex new viral disease, in which a strict balance between anti‐viral immune response and the ensuing organ inflammation has a critical role in determining the clinical course. In adults, compelling evidence exists indicating that an uncontrolled inflammatory response ("cytokine storm") is pivotal in determining disease progression and mortality. Children may rarely present with severe disease. Modulating factors related to the host's genetic factors, age‐related susceptibility, and the capability to mount appropriate immune responses might play a role in control virus load at an early stage and regulating the inflammatory reaction. Elucidating these mechanisms seems crucial in developing target therapies according to patient's age, immunologic status, and disease evolution in COVID‐19.