Circulating microbiota and metabolites: Insights into cardiovascular diseases. Issue 12 (29th November 2022)

• Record Type: Journal Article
• Authors: Khan, Ikram; Khan, Imran; Usman, Muhammad; Xiao Wei, Zhang; Ping, Xie; Khan, Sarmir; Khan, Feroz; Jianye, Zhou; Zhiqiang, Li; Lizhe, An
• Is Part Of: Journal of clinical laboratory analysis. Volume 36:Issue 12(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-29
• Subjects: bacteria -- blood microbiota -- cardiovascular diseases -- circulating metabolites -- non‐communicable diseases; Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.24779
• Languages: English
• ISSNs: 0887-8013

Abstract

Abstract: Background: In almost every country, cardiovascular diseases are the major cause of death, which are responsible for 17.7 million deaths worldwide, or 54% of all deaths. However, the latest evidence has shown that non‐communicable diseases such as obesity, diabetes, and cardiovascular events are significantly influenced by the blood microbiota and circulating metabolites. Methods: We searched online databases for the most recent related papers through the comprehensive international databases of the Institute of PubMed/ MEDLINE, ISI/WOS, and Scopus up to August 2022, using MESH terms and the related keywords in the English language. Considering the titles and abstracts, unrelated studies were excluded. The full texts of the remained studies were evaluated by authors, independently. Then, the studies' findings were assessed and reported. Results: The study demonstrated that the bacterial profiles of patients with cardiovascular diseases and healthy individuals are significantly different. The diseased patients showed a significantly high abundance of phylum Proteobacteria, an important Proteobacterial component known as lipopolysaccharides that has been linked to the pathogenesis of cardiovascular disease, while phylum Firmicutes were found in healthy individuals. It suggests that Proteobacteria has a direct role in the onset of cardiovascular disease. Conclusion: We focused on the blood bacterial composition and circulating microbial metabolites in their relationship with the etiology and onset of cardiovascular disease. However, the various genera and species in the results reported were not always identical. Therefore, the microbial community structure of blood was more complicated and thus required a more in‐depth exploration. Abstract : Cardiovascular diseases are the major cause of morbidity and mortality worldwide. Several traditional risk factors and their associations with cardiovascular diseases has well known, however, the comprehensive study on circulating microbiota and metabolites in cardiovascular diseases has not been well explored. For the current study, we searched the relevant and latest articles using comprehensive international databases of the Institute of PubMed/ MEDLINE, ISI/WOS, and Scopus up to August 2022, using MESH terms and the related keywords in the English language. The irrelevant data were excluded at the time. The result of the study shows that the blood microbiota of patients with cardiovascular diseases is significantly distinct from that of healthy individuals.