A Photo‐Responsive Hollow Manganese/Carbon Hybrid Nanosphere for Wound Disinfection and Healing. (2nd November 2022)

• Record Type: Journal Article
• Authors: Lu, Mingzhu; Li, Shanshan; Xiong, Xiaolu; Huang, Zhijun; Xu, Bolong; Liu, Yunhang; Wu, Qingyuan; Wu, Nier; Liu, Huiyu; Zhou, Dongsheng
• Is Part Of: Advanced functional materials. Volume 32:Number 51(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-02
• Subjects: multi‐drug resistant bacteria -- nanozymes -- photothermal effects -- wound disinfection -- wound healing; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202208061
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: The emergence of multi‐drug resistant (MDR) bacteria poses a serious threat to human health. It has become imperative to develop efficient antimicrobial strategies. Here, a manganese‐doped dopamine‐derived hollow carbon sphere (MnOx /HNCS) is developed as a nanozyme and photothermal agent for the synergistic treatment of MDR bacterial infections. MnOx /HNCS possesses oxidase, superoxide dismutase, and peroxidase like activities and implements self‐cascading enzymatic catalysis to produce superoxide anion (O2 − ), hydrogen peroxide (H2 O2 ), and hydroxyl radicals (OH). Importantly, near‐infrared light facilitates the electron transport of MnOx /HNCS, allowing it to exhibit stable photothermal effects and photo‐enhanced enzymatic activity. Thereby MnOx /HNCS displays a broad‐spectrum synergistic antibacterial efficiency in vitro against six MDR pathogens based on the above photo‐regulated properties. In vivo experiments further demonstrate the excellent antibacterial efficiency of MnOx /HNCS in the MDR bacteria‐infected wound model. Notably, MnOx /HNCS not only has excellent disinfection capacity, but also can accelerate wound healing by stimulating the deposition of the extracellular matrix and reepithelialization. This study proposes a promising antibiotics‐alternative broad‐spectrum antibacterial strategy and paves a new avenue for the establishment of multifunctional photo‐responsive synergistic therapeutic platform. Abstract : This study reports a photo‐responsive therapeutic platform, which combines photothermal therapy and photo‐enhanced catalytic therapy to kill multi‐drug resistant bacteria and suppresses further inflammation. Mn 2+ released from this nanoparticle and mild heat generated from its photothermal effect play important roles in wound healing by stimulating extracellular matrix disposition and reepithelialization.