A real-world, cross-sectional, community survey of symptoms and health-related quality of life of adults with acute myeloid leukemia. (26th March 2019)

• Record Type: Journal Article
• Authors: Mamolo, Carla M; Cappelleri, Joseph C; Hoang, Caroline J; Kim, Ruth; Hadfield, Anna; Middleton, Chloe; Rider, Alex; Walter, Roland B
• Is Part Of: Future oncology. Volume 15:Number 16(2019)
• Page Start: 1895
• Page End: 1909
• Publication Date: 2019-03-26
• Subjects: acute myeloid leukemia -- chemotherapy -- clinical practice -- community setting -- quality of life -- real-world; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2018-0842
• Languages: English
• ISSNs: 1479-6694

Abstract

Aim: We used Adelphi Real World Disease-Specific Programme data to characterize adults with newly diagnosed or relapsed/refractory de novo acute myeloid leukemia (AML).Materials & methods: Community-practice hematologists/oncologists completed patient record forms for their regular AML patients. Patients were invited to complete patient self-completion forms including 3-Level EuroQol 5-Dimensions (EQ-5D-3L) and Functional Assessment of Cancer Therapy–Leukemia (FACT-Leu) questionnaires.Results: Physicians provided patient record forms for 389 patients (339 newly diagnosed, 50 relapsed/refractory); 68 patients completed patient self-completion forms. Mean EQ-5D visual–analog scale and index and FACT-General scores were significantly lower than US population norms (p < 0.0001); health-related quality of life (HRQoL) scores were generally lower than 11 other cancers.Conclusion: HRQoL impairment is grave in AML. Efforts are needed to improve HRQoL in affected patients.