Circadian clock‐mediated nuclear receptors in cancer. Issue 12 (17th October 2022)

• Record Type: Journal Article
• Authors: Niu, Ya; Tang, Shuang
• Is Part Of: Journal of cellular physiology. Volume 237:Issue 12(2022)
• Page Start: 4428
• Page End: 4442
• Publication Date: 2022-10-17
• Subjects: cancer -- circadian rhythm -- clock -- nuclear receptors; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30905
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Circadian system coordinates the daily periodicity of physiological and biochemical functions to adapt to environmental changes. Circadian disruption has been identified to increase the risk of cancer and promote cancer progression, but the underlying mechanism remains unclear. And further mechanistic understanding of the crosstalk between clock components and cancer is urgent to achieve clinical anticancer benefits from chronochemotherapy. Recent studies discover that several nuclear receptors regulating circadian clock, also play crucial roles in mediating multiple cancer processes. In this review, we aim to summarize the latest developments of clock‐related nuclear receptors in cancer biology and dissect mechanistic insights into how nuclear receptors coordinate with circadian clock to regulate tumorigenesis and cancer treatment. A better understanding of circadian clock‐related nuclear receptors in cancer could help prevent tumorigenesis and improve anticancer efficacy.