Variability of clinically measured lung clearance index in children with cystic fibrosis. Issue 1 (2nd November 2022)

• Record Type: Journal Article
• Authors: Frauchiger, Bettina S.; Ramsey, Kathryn A.; Usemann, Jakob; Kieninger, Elisabeth; Casaulta, Carmen; Sirtes, Daniel; Yammine, Sophie; Spycher, Ben; Moeller, Alexander; Latzin, Philipp
• Is Part Of: Pediatric pulmonology. Volume 58:Issue 1(2023)
• Page Start: 197
• Page End: 205
• Publication Date: 2022-11-02
• Subjects: children -- cystic fibrosis -- lung; Pediatric respiratory diseases -- Periodicals; Pediatrics -- Periodicals; 618.922
• DOI: 10.1002/ppul.26180
• Languages: English
• ISSNs: 8755-6863

Abstract

Abstract: RATIONALE: The lung clearance index (LCI) is increasingly being used in the clinical surveillance of patients with cystic fibrosis (CF). However, there are limited data on long‐term variability and physiologically relevant changes in LCI during routine clinical surveillance. Objectives: To evaluate the long‐term variability of LCI and propose a threshold for a physiologically relevant change. Methods: In children aged 4–18 years with CF, LCI was measured every 3 months as part of routine clinical surveillance during 2011–2020 in two centers. The variability of LCI during periods of clinical stability was assessed using mixed‐effects models and was used to identify thresholds for physiologically relevant changes. Results: Repeated LCI measurements of acceptable quality ( N = 858) were available in 100 patients with CF; for 74 patients, 399 visits at clinical stability were available. The variability of repeated LCI measurements over time expressed as the coefficient of variation (CV%) was 7.4%. The upper limit of normal (ULN) for relative changes in LCI between visits was 19%. Conclusion: We report the variability of LCI in children and adolescents with CF during routine clinical surveillance. According to our data, a change in LCI beyond 19% may be considered physiologically relevant. These findings will help guide clinical decisions according to LCI changes.