Targeted Self‐assembly of Renal Clearable Cu2‐xSe to Induce Lysosome Swelling for Multimodal Imaging Guided Photothermal/Chemodynamic Synergistic Therapy. (10th October 2022)

• Record Type: Journal Article
• Authors: Luan, Xiaowei; Pan, Yongchun; Zhou, Yuyu; Zhou, Dongtao; Zhao, Wenjian; Zeng, Fei; Zhu, Zhenxing; Lu, Qiangbing; Lu, Qianglan; Gao, Yanfeng; He, Guanzhong; Lu, Minghui; Song, Yujun
• Is Part Of: Advanced functional materials. Volume 32:Number 51(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-10-10
• Subjects: lysosome cell deaths -- multimodal imaging -- phototherapy -- photothermal -- renal clearance -- self‐assemblies; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202208354
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Renal clearance is critical for nanodrug to avoid the long‐term body retention‐related side effects, while it is difficult to achieve efficient tumor accumulation and retention. The over‐developed lysosomes in cancer cells have become an emerging target for more precise and effective cancer therapy. Herein, a pH‐responsive reversible self‐assembled Cu2‐ x Se‐BSA, which can be renal cleared under neutral or basic conditions, is developed for selectively targeted aggregation in cancer lysosomes with enhanced tumor accumulation and retention. Moreover, the aggregation of Cu2‐ x Se‐BSA can enhance the photoacoustic imaging signal, photothermal therapy, and chemodynamic therapy capability. Cu2‐ x Se‐BSA accumulated in lysosomes cannot only induce lysosomes swelling, but also generate reactive oxygen species in situ, causing lysosomal membrane permeabilization and finally lysosomal cell death. Notably, the assembled Cu2‐ x Se‐BSA can dissociate to be renal clearable after the treatments are completed and left the acid tumor microenvironment, being of great significance both in scientific research and clinical trial. Abstract : This study represents a new method to synthesize renal clearable ultrasmall Cu2‐ x Se, with pH‐triggered revisable aggregation ability, by using BSA as a template. It performs well in selectively accumulating in tumor sites and aggregating in cancer lysosomes to induce lysosomal cell death, which could achieve right balance between renal‐clearable and theranostic properties and exhibits remarkable anticancer efficacy and high biosafety.