Remodelling of myelinated axons and oligodendrocyte differentiation is stimulated by environmental enrichment in the young adult brain. (27th October 2022)

• Record Type: Journal Article
• Authors: Nicholson, Madeline; Wood, Rhiannon J.; Gonsalvez, David G.; Hannan, Anthony J.; Fletcher, Jessica L.; Xiao, Junhua; Murray, Simon S.
• Is Part Of: European journal of neuroscience. Volume 56:Number 12(2022)
• Page Start: 6099
• Page End: 6114
• Publication Date: 2022-10-27
• Subjects: activity‐dependent plasticity -- differentiation -- environmental enrichment -- experience‐dependent plasticity -- myelin plasticity -- myelinated axon -- myelination -- oligodendrocyte -- OPC; Nervous system -- Periodicals; 612.8
• DOI: 10.1111/ejn.15840
• Languages: English
• ISSNs: 0953-816X

Abstract

Abstract: Oligodendrocyte production and myelination continues lifelong in the central nervous system (CNS), and all stages of this process can be adaptively regulated by neuronal activity. While artificial exogenous stimulation of neuronal circuits greatly enhances oligodendrocyte progenitor cell (OPC) production and increases myelination during development, the extent to which physiological stimuli replicates this is unclear, particularly in the adult CNS when the rate of new myelin addition slows. Here, we used environmental enrichment (EE) to physiologically stimulate neuronal activity for 6 weeks in 9‐week‐old C57BL/six male and female mice and found no increase in compact myelin in the corpus callosum or somatosensory cortex. Instead, we observed a global increase in callosal axon diameter with thicker myelin sheaths, elongated paranodes and shortened nodes of Ranvier. These findings indicate that EE induced the dynamic structural remodelling of myelinated axons. Additionally, we observed a global increase in the differentiation of OPCs and pre‐myelinating oligodendroglia in the corpus callosum and somatosensory cortex. Our findings of structural remodelling of myelinated axons in response to physiological neural stimuli during young adulthood provide important insights in understanding experience‐dependent myelin plasticity throughout the lifespan and provide a platform to investigate axon–myelin interactions in a physiologically relevant context. Abstract : Using environmental enrichment to physiologically induce neuroplasticity in the young adult mouse, we find dynamic structural remodelling of axons and their pre‐existing myelin sheaths. Additionally, we find that oligodendrocytes respond primarily with an increase in differentiation and regionally specific decreases in progenitor density. These results highlight diverse and context‐dependent mechanisms of myelin plasticity and advance our understanding of neurobiology across the lifespan.