Association between BNT162b2 vaccination and the development of delayed inflammatory reactions to hyaluronic acid‐based dermal fillers—A nationwide survey. (9th August 2022)

• Record Type: Journal Article
• Authors: Safir, Ari; Samuelov, Liat; Sprecher, Eli; Daniely, Danny; Artzi, Ofir
• Is Part Of: Journal of cosmetic dermatology. Volume 21:Number 10(2022)
• Page Start: 4107
• Page End: 4113
• Publication Date: 2022-08-09
• Subjects: BNT162b2 vaccination -- COVID‐19 vaccination -- delayed inflammatory reaction -- dermal fillers -- hyaluronic acid; Skin -- Diseases -- Treatment -- Periodicals; Lasers in surgery -- Periodicals; Skin -- Pathophysiology -- Periodicals; Surgery, Plastic -- Periodicals; 616.5
• DOI: 10.1111/jocd.15260
• Languages: English
• ISSNs: 1473-2130

Abstract

Abstract: Background: Delayed inflammatory reactions (DIRs) to hyaluronic acid‐based dermal fillers following COVID‐19 vaccination has been reported in a few anecdotal reports and small series of cases. Aim: To evaluate the clinical characteristics, incidence, and management options relevant to BNT162b2 vaccination‐associated DIR—A nationwide survey was conducted. Methods: An online self‐administered survey was sent to physicians who actively practice tissue filler injections. The data acquired included demographic and clinical characteristics of relevant DIR cases. Results: Out of 262 responders, 20 cases with DIR following the vaccination were reported. 35% and 65% occurred shortly after the first and second vaccination dose, respectively. Overall, 65% of the DIRs appeared ≤5 days after vaccine administration and most DIRs resolved within 21 days. The filler's volume ( p = 0.016) was associated with higher DIR severity, and the same tendency was noted among some filler types and locations of injection. Medical intervention was provided in 12 (60%) cases. Conclusion: DIR associated with BNT162b2 vaccination is rare and tends to resolve spontaneously or with short‐term medical intervention.