2022 American College of Rheumatology/EULAR Classification Criteria for Giant Cell Arteritis. Issue 12 (8th November 2022)

• Record Type: Journal Article
• Authors: Ponte, Cristina; Grayson, Peter C.; Robson, Joanna C.; Suppiah, Ravi; Gribbons, Katherine Bates; Judge, Andrew; Craven, Anthea; Khalid, Sara; Hutchings, Andrew; Watts, Richard A.; Merkel, Peter A.; Luqmani, Raashid A.
• Other Names: Gatenby Paul investigator.; Hill Catherine investigator.; Ranganathan Dwarakanathan investigator.; Kronbichler Andreas investigator.; Blockmans Daniel investigator.; Barra Lillian investigator.; Carette Simon investigator.; Pagnoux Christian investigator.; Dhindsa Navjot investigator.; Fifi‐Mah Aurore investigator.; Khalidi Nader investigator.; Liang Patrick investigator.; Milman Nataliya investigator.; Pineau Christian investigator.; Tian Xinping investigator.; Wang Guochun investigator.; Wang Tian investigator.; Zhao Ming‐hui investigator.; Tesar Vladimir investigator.; Baslund Bo investigator.; Hammam Nevin investigator.; Shahin Amira investigator.; Pirila Laura investigator.; Putaala Jukka investigator.; Hellmich Bernhard investigator.; Henes Jörg investigator.; Holle Julia investigator.; Moosig Frank investigator.; Lamprecht Peter investigator.; Neumann Thomas investigator.; Schmidt Wolfgang investigator.; Sunderkoetter Cord investigator.; Szekanecz Zoltan investigator.; Danda Debashish investigator.; Das Siddharth investigator.; Gupta Rajiva investigator.; Rajasekhar Liza investigator.; Sharma Aman investigator.; Wagh Shrikant investigator.; Clarkson Michael investigator.; Molloy Eamonn investigator.; Salvarani Carlo investigator.; Schiavon Franco investigator.; Tombetti Enrico investigator.; Vaglio Augusto investigator.; Amano Koichi investigator.; Arimura Yoshihiro investigator.; Dobashi Hiroaki investigator.; Fujimoto Shouichi investigator.; Harigai Masayoshi investigator.; Hirano Fumio investigator.; Hirahashi Junichi investigator.; Honma Sakae investigator.; Kawakami Tamihiro investigator.; Kobayashi Shigeto investigator.; Kono Hajime investigator.; Makino Hirofumi investigator.; Matsui Kazuo investigator.; Muso Eri investigator.; Suzuki Kazuo investigator.; Ikeda Kei investigator.; Takeuchi Tsutomu investigator.; Tsukamoto Tatsuo investigator.; Uchida Shunya investigator.; Wada Takashi investigator.; Yamada Hidehiro investigator.; Yamagata Kunihiro investigator.; Yumura Wako investigator.; Lai Kan Sow investigator.; Flores‐Suarez Luis Felipe investigator.; Hinojosa‐Azaola Andrea investigator.; Rutgers Bram investigator.; Tak Paul‐Peter investigator.; Grainger Rebecca investigator.; Quincey Vicki investigator.; Stamp Lisa investigator.; Suppiah Ravi investigator.; Besada Emilio investigator.; Diamantopoulos Andreas investigator.; Sznajd Jan investigator.; Azevedo Elsa investigator.; Geraldes Ruth investigator.; Rodrigues Miguel investigator.; Santos Ernestina investigator.; Song Yeong‐Wook investigator.; Moiseev Sergey investigator.; Hočevar Alojzija investigator.; Cid Maria Cinta investigator.; Moreno Xavier Solanich investigator.; Atukorala Inoshi investigator.; Berglin Ewa investigator.; Mohammed Aladdin investigator.; Segelmark Mårten investigator.; Daikeler Thomas investigator.; Direskeneli Haner investigator.; Hatemi Gulen investigator.; Kamali Sevil investigator.; Karadağ Ömer investigator.; Pehlevan Seval investigator.; Adler Matthew investigator.; Basu Neil investigator.; Bruce Iain investigator.; Chakravarty Kuntal investigator.; Dasgupta Bhaskar investigator.; Flossmann Oliver investigator.; Gendi Nagui investigator.; Hassan Alaa investigator.; Hoyles Rachel investigator.; Jayne David investigator.; Jones Colin investigator.; Klocke Rainer investigator.; Lanyon Peter investigator.; Laversuch Cathy investigator.; Luqmani Raashid investigator.; Robson Joanna investigator.; Magliano Malgorzata investigator.; Mason Justin investigator.; Maw Win Win investigator.; McInnes Iain investigator.; Mclaren John investigator.; Morgan Matthew investigator.; Morgan Ann investigator.; Mukhtyar Chetan investigator.; O'Riordan Edmond investigator.; Patel Sanjeev investigator.; Peall Adrian investigator.; Robson Joanna investigator.; Venkatachalam Srinivasan investigator.; Vermaak Erin investigator.; Menon Ajit investigator.; Watts Richard investigator.; Yee Chee‐Seng investigator.; Albert Daniel investigator.; Calabrese Leonard investigator.; Chung Sharon investigator.; Forbess Lindsy investigator.; Gaffo Angelo investigator.; Gewurz‐Singer Ora investigator.; Grayson Peter investigator.; Liang Kimberly investigator.; Matteson Eric investigator.; Merkel Peter A. investigator.; Rhee Rennie investigator.; Springer Jason investigator.; Sreih Antoine investigator.;
• Is Part Of: Arthritis & rheumatology. Volume 74:Issue 12(2022)
• Page Start: 1881
• Page End: 1889
• Publication Date: 2022-11-08
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/art.42325
• Languages: English
• ISSNs: 2326-5191

Abstract

Abstract : Objective: To develop and validate updated classification criteria for giant cell arteritis (GCA). Methods: Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 6 phases: 1) identification of candidate items, 2) prospective collection of candidate items present at the time of diagnosis, 3) expert panel review of cases, 4) data‐driven reduction of candidate items, 5) derivation of a points‐based risk classification score in a development data set, and 6) validation in an independent data set. Results: The development data set consisted of 518 cases of GCA and 536 comparators. The validation data set consisted of 238 cases of GCA and 213 comparators. Age ≥50 years at diagnosis was an absolute requirement for classification. The final criteria items and weights were as follows: positive temporal artery biopsy or temporal artery halo sign on ultrasound (+5); erythrocyte sedimentation rate ≥50 mm/hour or C‐reactive protein ≥10 mg/liter (+3); sudden visual loss (+3); morning stiffness in shoulders or neck, jaw or tongue claudication, new temporal headache, scalp tenderness, temporal artery abnormality on vascular examination, bilateral axillary involvement on imaging, and fluorodeoxyglucose–positron emission tomography activity throughout the aorta (+2 each). A patient could be classified as having GCA with a cumulative score of ≥6 points. When these criteria were tested in the validation data set, the model area under the curve was 0.91 (95% confidence interval [95% CI] 0.88–0.94) with a sensitivity of 87.0% (95% CI 82.0–91.0%) and specificity of 94.8% (95% CI 91.0–97.4%). Conclusion: The 2022 American College of Rheumatology/EULAR GCA classification criteria are now validated for use in clinical research.