Effect of calcitriol treatment on arterial stiffness in people with type 2 diabetes and stage 3 chronic kidney disease. Issue 1 (25th August 2022)

• Record Type: Journal Article
• Authors: Karalliedde, Janaka; Fountoulakis, Nikolaos; Corcillo, Antonella; Maltese, Giuseppe; Flaquer, Maria; Stathi, Dimitra; Mangelis, Anastasios; Panagiotou, Angeliki; Ayis, Salma; Thomas, Stephen; Gnudi, Luigi
• Is Part Of: British journal of clinical pharmacology. Volume 89:Issue 1(2023)
• Page Start: 279
• Page End: 289
• Publication Date: 2022-08-25
• Subjects: arterial stiffness -- CKD -- type 2 diabetes -- vitamin D; Pharmacology -- Periodicals; Drugs -- Periodicals; 615.1
• DOI: 10.1111/bcp.15484
• Languages: English
• ISSNs: 0306-5251

Abstract

Abstract : Aims: Active vitamin D deficiency is associated with increased aortic‐pulse wave velocity (Ao‐PWV) in people with type 2 diabetes (T2DM) and chronic kidney disease (CKD). There are no randomised controlled trials investigating the effect of active vitamin D treatment on Ao‐PWV in people with T2DM and CKD. Methods: A 48‐week duration single‐centre randomised double‐blind parallel‐group trial examined the impact of oral 1, 25 dihydroxyvitamin D (calcitriol 0.25 mcg OD) as compared to placebo on a primary endpoint of Ao‐PWV. People with T2DM and stable stage 3 CKD with intact parathyroid hormone (iPTH) level >30 pg/mL were eligible. Results: In total, 127 (70% male) people were randomised (calcitriol n = 64 or placebo n = 63). There was no change in Ao‐PWV observed, mean ± standard deviation (SD), in the calcitriol group of 11.79 (±2.5) to 12.08 (3.0) m/s as compared to 10.90 (±2.4) to 11.39 (±2.6) m/s with placebo. The between‐treatment group adjusted mean (95% confidence interval [(CI]] change was 0.23 (−0.58 to 1.05) m/s, P = .57. No effect of calcitriol was observed on central arterial pressures, albuminuria, serum calcium or phosphate levels. However, iPTH fell with calcitriol treatment (mean [95% CI] between‐group difference of −27.8 (−42.3 to −13.2) pg/mL, P < .001. Conclusion: In T2DM and stage 3 CKD, calcitriol as compared to placebo does not improve Ao‐PWV or other markers of arterial stiffness. Our study does not provide evidence for the use of active vitamin D for improving arterial stiffness in T2DM with stage 3 CKD.