Immunohistochemical expression of regulatory T cells (CD4+ CD25+ bright FOXP3+) in pemphigus patients. (1st June 2022)

• Record Type: Journal Article
• Authors: Abd El‐Magid, Wafaa Mohamed; Ahmed, Sheren FM; Assaf, Hanan; Abd Elkhalek, Reham Ebraheem; Mohamed, Marwa
• Is Part Of: Journal of cosmetic dermatology. Volume 21:Number 10(2022)
• Page Start: 4871
• Page End: 4876
• Publication Date: 2022-06-01
• Subjects: CD25 -- CD4 -- Foxp3 -- immunohistochemistry -- pemphigus; Skin -- Diseases -- Treatment -- Periodicals; Lasers in surgery -- Periodicals; Skin -- Pathophysiology -- Periodicals; Surgery, Plastic -- Periodicals; 616.5
• DOI: 10.1111/jocd.14854
• Languages: English
• ISSNs: 1473-2130

Abstract

Abstract: Background: Pemphigus is a series of autoimmune skin disorders caused by IgG. Regulatory T cells (Tregs) are a subset of CD4+ T cells that mostly block pathogenic immune responses mediated by self‐reactive cells; therefore, a lack of Tregs or a malfunction in their activity could lead to a loss of tolerance and the development of autoimmunity. Aims: To evaluate the expression of lesional and perilesional Treg markers (CD4 + CD25 + bright FOXP3 + ) in pemphigus patients. Patients and methods: Twenty‐three pemphigus patients and 20 healthy controls were included in this study. The expression of CD4, CD25, and Foxp3 was evaluated by immunohistochemistry. Results: There was statistically significant increase in CD4+ T lymphocytes in lesional skin of pemphigus compared to perilesional skin and control group ( p ‐value: 0.001). There was statistically significant decrease in CD25 + and Foxp3 + cells in lesional skin compared to perilesional and control group ( p ‐value: <0.001, 0.025, respectively). Conclusion: The reduction of lesional skin Tregs may play an important role in the pemphigus pathogenesis.