2022 American College of Rheumatology/EULAR Classification Criteria for Takayasu Arteritis. Issue 12 (8th November 2022)

• Record Type: Journal Article
• Authors: Grayson, Peter C.; Ponte, Cristina; Suppiah, Ravi; Robson, Joanna C.; Gribbons, Katherine Bates; Judge, Andrew; Craven, Anthea; Khalid, Sara; Hutchings, Andrew; Danda, Debashish; Luqmani, Raashid A.; Watts, Richard A.; Merkel, Peter A.
• Other Names: Gatenby Paul investigator.; Hill Catherine investigator.; Ranganathan Dwarakanathan investigator.; Kronbichler Andreas investigator.; Blockmans Daniel investigator.; Barra Lillian investigator.; Carette Simon investigator.; Pagnoux Christian investigator.; Dhindsa Navjot investigator.; Fifi‐Mah Aurore investigator.; Khalidi Nader investigator.; Liang Patrick investigator.; Milman Nataliya investigator.; Pineau Christian investigator.; Tian Xinping investigator.; Wang Guochun investigator.; Wang Tian investigator.; Zhao Ming‐hui investigator.; Tesar Vladimir investigator.; Baslund Bo investigator.; Hammam Nevin investigator.; Shahin Amira investigator.; Pirila Laura investigator.; Putaala Jukka investigator.; Hellmich Bernhard investigator.; Henes Jörg investigator.; Holle Julia investigator.; Lamprecht Peter investigator.; Moosig Frank investigator.; Neumann Thomas investigator.; Schmidt Wolfgang investigator.; Sunderkoettey Cord investigator.; Szekanecz Zoltan investigator.; Danda Debashish investigator.; Das Siddharth investigator.; Gupta Rajiva investigator.; Rajasekhar Liza investigator.; Sharma Aman investigator.; Wagh Shrikant investigator.; Clarkson Michael investigator.; Molloy Eamonn investigator.; Salvarani Carlo investigator.; Schiavon Franco investigator.; Tombetti Enrico investigator.; Vaglio Augusto investigator.; Amano Koichi investigator.; Arimura Yoshihiro investigator.; Dobashi Hiroaki investigator.; Fujimoto Shouichi investigator.; Harigai Masayoshi investigator.; Hirano Fumio investigator.; Hirahashi Junichi investigator.; Honma Sakae investigator.; Kawakami Tamihiro investigator.; Kobayashi Shigeto investigator.; Kono Hajime investigator.; Makino Hirofumi investigator.; Matsui Kazuo investigator.; Muso Eri investigator.; Suzuki Kazuo investigator.; Ikeda Kei investigator.; Takeuchi Tsutomu investigator.; Tsukamoto Tatsuo investigator.; Uchida Shunya investigator.; Wada Takashi investigator.; Yamada Hidehiro investigator.; Yamagata Kunihiro investigator.; Yumura Wako investigator.; Lai Kan Sow investigator.; Flores‐Suarez Luis Felipe investigator.; Hinojosa‐Azaola Andrea investigator.; Rutgers Bram investigator.; Tak Paul‐Peter investigator.; Grainger Rebecca investigator.; Quincey Vicki investigator.; Stamp Lisa investigator.; Suppiah Ravi investigator.; Besada Emilio investigator.; Diamantopoulos Andreas investigator.; Sznajd Jan investigator.; Azevedo Elsa investigator.; Geraldes Ruth investigator.; Rodrigues Miguel investigator.; Santos Ernestina investigator.; Song Yeong‐Wook investigator.; Moiseev Sergey investigator.; Hočevar Alojzija investigator.; Cid Maria Cinta investigator.; Moreno Xavier Solanich investigator.; Atukorala Inoshi investigator.; Berglin Ewa investigator.; Mohammed Aladdin investigator.; Segelmark Mårten investigator.; Daikeler Thomas investigator.; Direskeneli Haner investigator.; Hatemi Gulen investigator.; Kamali Sevil investigator.; Karadağ Ömer investigator.; Pehlevan Seval investigator.; Adler Matthew investigator.; Basu Neil investigator.; Bruce Iain investigator.; Chakravarty Kuntal investigator.; Dasgupta Bhaskar investigator.; Flossmann Oliver investigator.; Gendi Nagui investigator.; Hassan Alaa investigator.; Hoyles Rachel investigator.; Jayne David investigator.; Jones Colin investigator.; Klocke Rainer investigator.; Lanyon Peter investigator.; Laversuch Cathy investigator.; Luqmani Raashid investigator.; Robson Joanna investigator.; Magliano Malgorzata investigator.; Mason Justin investigator.; Maw Win Win investigator.; McInnes Iain investigator.; Mclaren John investigator.; Morgan Matthew investigator.; Morgan Ann investigator.; Mukhtyar Chetan investigator.; O'Riordan Edmond investigator.; Patel Sanjeev investigator.; Peall Adrian investigator.; Robson Joanna investigator.; Venkatachalam Srinivasan investigator.; Vermaak Erin investigator.; Menon Ajit investigator.; Watts Richard investigator.; Yee Chee‐Seng investigator.; Albert Daniel investigator.; Calabrese Leonard investigator.; Chung Sharon investigator.; Forbess Lindsy investigator.; Gaffo Angelo investigator.; Gewurz‐Singer Ora investigator.; Grayson Peter investigator.; Liang Kimberly investigator.; Matteson Eric investigator.; Merkel Peter A. investigator.; Rhee Rennie investigator.; Springer Jason investigator.; Sreih Antoine investigator.;
• Is Part Of: Arthritis & rheumatology. Volume 74:Issue 12(2022)
• Page Start: 1872
• Page End: 1880
• Publication Date: 2022-11-08
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/art.42324
• Languages: English
• ISSNs: 2326-5191

Abstract

Abstract : Objective: To develop and validate new classification criteria for Takayasu arteritis (TAK). Methods: Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 6 phases: 1) identification of candidate criteria items, 2) collection of candidate items present at diagnosis, 3) expert panel review of cases, 4) data‐driven reduction of candidate items, 5) derivation of a points‐based classification score in a development data set, and 6) validation in an independent data set. Results: The development data set consisted of 316 cases of TAK and 323 comparators. The validation data set consisted of an additional 146 cases of TAK and 127 comparators. Age ≤60 years at diagnosis and imaging evidence of large‐vessel vasculitis were absolute requirements to classify a patient as having TAK. The final criteria items and weights were as follows: female sex (+1), angina (+2), limb claudication (+2), arterial bruit (+2), reduced upper extremity pulse (+2), reduced pulse or tenderness of a carotid artery (+2), blood pressure difference between arms of ≥20 mm Hg (+1), number of affected arterial territories (+1 to +3), paired artery involvement (+1), and abdominal aorta plus renal or mesenteric involvement (+3). A patient could be classified as having TAK with a cumulative score of ≥5 points. When these criteria were tested in the validation data set, the model area under the curve was 0.97 (95% confidence interval [95% CI] 0.94–0.99) with a sensitivity of 93.8% (95% CI 88.6–97.1%) and specificity of 99.2% (95% CI 96.7–100.0%). Conclusion: The 2022 American College of Rheumatology/EULAR classification criteria for TAK are now validated for use in research.