Three new cassane-type diterpenoids from Caesalpinia sinensis. Issue 12 (2nd December 2022)

• Record Type: Journal Article
• Authors: Chen, Yuan-Kai; Fan, Miao-Yin; Zhang, Ya-Mei; Zhang, Pu-Zhao; Shu, Ren-Geng
• Is Part Of: Journal of Asian natural products research. Volume 24:Issue 12(2022)
• Page Start: 1134
• Page End: 1140
• Publication Date: 2022-12-02
• Subjects: Fabaceae -- Caesalpinia sinensis -- cassane diterpenoids -- PTP1B; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2022.2026933
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Three new cassane-type diterpenoids, namely, (4 S )-6 β, 12 α, 19-trihydroxy-cass-13(15)-en-16, 12-olide (1 ), cass-13(15)-en-​16, 12-olide (2 ), and 12 α -hydroxy-cass-13(15)-en-16, 12-olide (3 ), were isolated from the seeds of Caesalpinia sinensis. The structures of 1 –3 were established by extensive spectroscopic analysis, and their absolute configurations were assigned by electronic circular dichroism (ECD) calculations. The inhibitory activities against PTP1B of the isolated compounds were evaluated. The results showed that compound 2 possessed PTP1B inhibitory activity with an IC50 value of 217.45 ± 36.4 μM. Graphical Abstract: UF0001