Cutting-edge strategies and critical advancements in characterization and quantification of metabolites concerning translational metabolomics. (2nd October 2022)

• Record Type: Journal Article
• Authors: Pillai, Megha Sajakumar; Paritala, Sree Teja; Shah, Ravi P.; Sharma, Nitish; Sengupta, Pinaki
• Is Part Of: Drug metabolism reviews. Volume 54:Number 4(2022)
• Page Start: 401
• Page End: 426
• Publication Date: 2022-10-02
• Subjects: Metabolomics and translational research -- mass spectrometry -- biomarkers -- cutting-edge techniques -- personalized medicine; Drugs -- Metabolism -- Periodicals; Pharmacokinetics -- Periodicals; Pharmaceutical Preparations -- metabolism -- Periodicals; 615
• DOI: 10.1080/03602532.2022.2125987
• Languages: English
• ISSNs: 0360-2532

Abstract

Abstract: Despite remarkable progress in drug discovery strategies, significant challenges are still remaining in translating new insights into clinical applications. Scientists are devising creative approaches to bridge the gap between scientific and translational research. Metabolomics is a unique field among other omics techniques for identifying novel metabolites and biomarkers. Fortunately, characterization and quantification of metabolites are becoming faster due to the progress in the field of orthogonal analytical techniques. This review detailed the advancement in the progress of sample preparation, and data processing techniques including data mining tools, database, and their quality control (QC). Advances in data processing tools make it easier to acquire unbiased data that includes a diverse set of metabolites. In addition, novel breakthroughs including, miniaturization as well as their integration with other devices, metabolite array technology, and crystalline sponge-based method have led to faster, more efficient, cost-effective, and holistic metabolomic analysis. The use of cutting-edge techniques to identify the human metabolite, including biomarkers has proven to be advantageous in terms of early disease identification, tracking the progression of illness, and possibility of personalized treatments. This review addressed the constraints of current metabolomics research, which are impeding the facilitation of translation of research from bench to bedside. Nevertheless, the possible way out from such constraints and future direction of translational metabolomics has been conferred.