Antimicrobial oral lavage reduces the SARS-CoV-2 load in intubated patients: randomized clinical trial. Issue 1 (31st December 2023)

• Record Type: Journal Article
• Authors: Bezinelli, Letícia Mello; Corrêa, Luciana; Beyerstedt, Stephany; Rangel, Érika Bevilaqua; Benitez, Carlos; Hamerschlak, Nelson; Pinho, João Renato Rebello; Heller, Debora; Eduardo, Fernanda de Paula
• Is Part Of: Journal of oral microbiology. Volume 15:Issue 1(2023)
• Publication Date: 2023-12-31
• Subjects: SARS-CoV-2 -- COVID-19 -- Orotracheal intubation -- Oral fluid -- Chlorhexidine -- Hydrogen peroxide; Mouth -- Microbiology -- Periodicals; Medical microbiology -- Periodicals; Mouth Diseases -- microbiology; Mouth -- microbiology; Medical microbiology; Mouth -- Microbiology; Oral Pathology; Microbiology; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; Electronic journals; 616.31
• DOI: 10.1080/20002297.2022.2152179
• Languages: English
• ISSNs: 2000-2297

Abstract

ABSTRACT: Background: The oral cavity can be a reservoir for SARS-CoV-2 and may play a crucial role in the viral transmission in the hospital environment. Objective: To investigate whether an oral hygiene protocol with chlorhexidine (CHX) used alone and in combination with hydrogen peroxide (HP) in the intensive care unit was effective in reducing the SARS-CoV-2 viral load in the oral cavity. Methods: SARS-CoV-2 viral load was measured on oral fluid samples collected from patients undergoing orotracheal intubation. The study sample was randomly in: CHX group (n = 19) - oral rinse using only 0.12% CHX solution; HP+CHX group (n = 24) - oral rinse with 1.5% HP and 0.12% CHX. The samples were collected before the interventions (T0), immediately (T1), 30 minutes (T2) and 60 minutes (T3) after the procedure. Results: A significant viral load reduction was observed at T1 (mean ± SD:–0.57 ± 0.19 log10;–73.2%;p = 0.022) in the HP+CHX group. No statistically significant differences between any time points were observed in the CHX group. Conclusion: The HP+CHX oral rinses significantly reduced the SARS-CoV-2 viral load in the oral fluid immediately after the procedure. The CHX oral rinse alone did not result in any significant viral load reductions.