Ag(i)-catalyzed cyclization of o-alkynylacetophenones facilitated through acetal formation: synthesis of C3-naphthyl indole derivatives. Issue 48 (23rd November 2022)

• Record Type: Journal Article
• Authors: Ramesh, Golla; Srivardhan, Valmuri; Balamurugan, Rengarajan
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 48(2022)
• Page Start: 9698
• Page End: 9702
• Publication Date: 2022-11-23
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob01873j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Synthesis of C3-naphthylindoles has been achieved from o -alkynylacetophenones under acetalization conditions using trimethyl orthoformate and AgOTf. Abstract : A mild method for an efficient synthesis of C3-naphthyl indoles from o -alkynylacetophenones has been developed. This Ag-catalyzed transformation is assisted by the acetal formed under the reaction condition employing trimethyl orthoformate (TMOF). The role of acetal in promoting the reaction under ambient conditions has been established with control experiments. A range of C3-naphthyl indole derivatives have been synthesized in moderate to very good yields.