Metal–phenolic networks acted as a novel bio-filler of a barrier membrane to improve guided bone regeneration via manipulating osteoimmunomodulation. Issue 48 (5th December 2022)

• Record Type: Journal Article
• Authors: Ren, Lulu; Gong, Pei; Gao, Xinghui; Wang, Qian; Xie, Li; Tang, Wei; Long, Jie; Liu, Can; Tian, Weidong; He, Min
• Is Part Of: Journal of materials chemistry. Volume 10:Issue 48(2022)
• Page Start: 10128
• Page End: 10138
• Publication Date: 2022-12-05
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d2tb01804g
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Our work is a pioneering work in exploring MPNs as a novel type of bio-filler. Our work provides a new platform for controllable release of bioactive metal ions and a universal pathway to obtain multi-functional immunomodulatory biocomposites. Abstract : A guided bone tissue regeneration membrane (GBRM) is traditionally viewed as an inert physical barrier to isolate soft tissue from the bone defect area. However, as a "foreign body", the implantation of a GBRM would inevitably modulate immune response and subsequently affect bone dynamics. Herein, we developed strontium ion (Sr 2+ )-based metal–phenolic network complexes (MPNs) as a novel type of bio-filler to manipulate the osteoimmunomodulation of the advanced GBRM. For controllable delivery of Sr 2+ depending on the difference in affinity between phenolic ligands and Sr 2+, tannic acid (TA), epigallocatechin gallate (EGCG), and epigallocatechin (EGC) were selected to chelate with Sr 2+ . The formed MPNs were incorporated into PCL nanofibrous membranes by blending electrospinning. Among them, TA/Sr based MPN particles displayed the most sustainable release profile of phenolic ligands and Sr 2+ . Further investigations demonstrated that Sr 2+ could not only directly promote osteogenic differentiation of BMSCs, but also manipulate an anti-inflammatory osteoimmune microenvironment in a synergistic manner with TA, thus enhancing osteogenesis and inhibiting bone resorption. The rat alveolar bone defect model also confirmed that the TA/Sr nanoparticle modified membrane displayed better bone regeneration performance than the pure PCL membrane via inhibiting bone resorption. This work provides a new platform for controllable delivery of bioactive nutrient elements, and holds great promise for advancing multi-functional biocomposites.