Interactions Between Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Major Respiratory Viruses in Human Nasal Epithelium. (29th August 2022)

• Record Type: Journal Article
• Authors: Pizzorno, Andrés; Padey, Blandine; Dulière, Victoria; Mouton, William; Oliva, Justine; Laurent, Emilie; Milesi, Cedrine; Lina, Bruno; Traversier, Aurelien; Julien, Thomas; Trouillet-Assant, Sophie; Rosa-Calatrava, Manuel; Terrier, Olivier
• Is Part Of: Journal of infectious diseases. Volume 226:Number 12(2022)
• Page Start: 2095
• Page End: 2104
• Publication Date: 2022-08-29
• Subjects: SARS-CoV-2 -- human metapneumovirus -- human rhinovirus -- influenza virus -- respiratory syncytial virus -- virus-virus interactions; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiac357
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), along with extensive nonpharmacological interventions, have profoundly altered the epidemiology of major respiratory viruses. Some studies have described virus-virus interactions, particularly manifested by viral interference mechanisms at different scales. However, our knowledge of the interactions between SARS-CoV-2 and other respiratory viruses remains incomplete. Here, we studied the interactions between SARS-CoV-2 and several respiratory viruses (influenza, respiratory syncytial virus, human metapneumovirus, and human rhinovirus) in a reconstituted human epithelial airway model, exploring different scenarios affecting the sequence and timing of coinfections. We show that the virus type and sequence of infections are key factors in virus-virus interactions, the primary infection having a determinant role in the immune response to the secondary infection. Abstract : We show that the virus type and the sequence of infections are key parameters of virus-virus interactions, having the impact of primary infections on the regulation of the immune response a determinant role in the outcome of secondary infections.