Iminophosphine platinum(II) complexes containing long chain aniline derivatives: synthesis, characterization, and anticancer properties. (15th January 2023)

• Record Type: Journal Article
• Authors: Yuan Hsu, Sung; Murphy, Maia C.; Smolensky, Nicole T.; Vogels, Christopher M.; Lebel, Andréa A.; Masuda, Jason D.; Boudreau, Luc H.; Morin, Pier Jr.; Westcott, Stephen A.
• Is Part Of: Polyhedron. Volume 230(2023)
• Publication Date: 2023-01-15
• Subjects: Anticancer -- Glioma -- Iminophosphine -- Phosphorus -- Platinum; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2022.116236
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: A series of iminophosphine ligands containing aliphatic chains of varying lengths have been synthesized as well as their corresponding platinum complexes. All compounds have been characterized using multi-nuclear NMR spectroscopy as well as an X-ray structure of one of the platinum complexes. The cytotoxic activities of the platinum complexes against two glioma cell lines were examined using the MTT method. Abstract: A series of iminophosphine ligands (1a -g ) have been prepared from the condensation reaction of 2-(diphenylphosphino)benzaldehyde with aniline and aniline derivatives containing linear hydrocarbon chains of varying lengths in the para position. The corresponding platinum(II) complexes (2a -g ) were synthesized by reaction of [PtCl2 (η 2 -coe)]2 (coe = cis -cyclooctene) and two equivalents of 1a -g . Full characterization of all new ligands and platinum complexes was performed including multi-nuclear NMR spectroscopy as well as an X-ray diffraction study for compound 2d (derived from 4-hexylaniline). The cytotoxic properties of the platinum complexes against two glioma cell lines using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) colorimetric method were examined.