Pathologic features and differential diagnosis of chronic hepatitis. Issue 1 (January 2023)

• Record Type: Journal Article
• Authors: Choi, Won-Tak; Gill, Ryan M.
• Is Part Of: Diagnostic histopathology. Volume 29:Issue 1(2023)
• Page Start: 12
• Page End: 22
• Publication Date: 2023-01
• Subjects: alpha-1-antitrypsin -- autoimmune hepatitis -- chronic hepatitis -- drug -- fatty liver disease -- hepatitis B -- hepatitis C -- steatohepatitis -- Wilson disease; Histology, Pathological -- Periodicals; Cytodiagnosis -- Periodicals; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; Histopathologie -- Périodiques; Pathologie -- Périodiques; Cytodiagnostics -- Périodiques; Diagnostics biologiques -- Périodiques; Histologie -- Technique -- Périodiques; Electronic journals; 616.07582
• DOI: 10.1016/j.mpdhp.2022.10.003
• Languages: English
• ISSNs: 1756-2317

Abstract

Abstract: Persistent or relapsing hepatitic liver injury for more than 6 months results in chronic hepatitis, a broad category that includes the most common liver diseases: viral hepatitis, autoimmune hepatitis, drug-induced liver injury, and fatty liver disease, as well as less common inherited metabolic disorders such as Wilson disease and alpha-1-antitrypsin deficiency. Chronic cholestatic liver disease may also progress to advanced fibrosis and can be mistaken for a chronic hepatitis. Histologic features may overlap, especially at an advanced stage, and thus morphologic findings together with the overall clinical context play a critical role in establishing an accurate diagnosis. This review describes pathologic and clinical features of a spectrum of hepatitic liver disease that can cause chronic hepatitis, as well as diagnostic testing used to establish a diagnosis or distinguish among these entities.