Minimum-incision trans-subclavian transcatheter aortic valve replacement with regional anesthesia. Issue 2 (February 2023)

• Record Type: Journal Article
• Authors: Domoto, Satoru; Nakazawa, Keisuke; Yamaguchi, Junichi; Hayakawa, Minako; Otsuki, Hisao; Inagaki, Yusuke; Saito, Chihiro; Arashi, Hiroyuki; Kogure, Tomohito; Niinami, Hiroshi
• Is Part Of: Journal of cardiology. Volume 81:Issue 2(2023)
• Page Start: 131
• Page End: 137
• Publication Date: 2023-02
• Subjects: TAVR transcathter aortic valve replacement -- AS aortic stenosis -- TF transfemoral -- TS trans-subclavian -- SA subclavian artery -- GA general anesthesia -- MITS-TAVR minimum-incision trans-subclaviantranscathter aortic valve replacement -- ICU intensive care unit -- RA regional anesthesia -- MBP mean blood pressure -- OR operating room; Transsubclavian approach -- Transcathether aortic valve replacement -- Regional anesthesia; Cardiology -- Periodicals; 616.12
• DOI: 10.1016/j.jjcc.2022.07.006
• Languages: English
• ISSNs: 0914-5087

Abstract

Abstract: Background: Minimum-incision trans-subclavian transcatheter aortic valve replacement (MITS-TAVR) is usually performed in patients who are contraindicated for transfemoral TAVR, under regional anesthesia (RA). This study aimed to evaluate the safety and efficacy of MITS-TAVR under RA compared to MITS-TAVR under general anesthesia (GA). Methods: This single-center observational study included 44 consecutive patients who underwent MITS-TAVR under RA (RA group, n = 19) and GA (GA group, n = 25). RA was achieved using an ultrasound-guided nerve block. Results: The rates of respiratory disease (RA vs. GA, 36.8 % vs. 4.0 %; p < 0.01) and dialysis (79.0 % vs. 0 %; p < 0.01) were significantly higher in the RA group. STS score was significantly higher in the RA group (RA vs. GA, 10.8 ± 1.06 % vs. 7.87 ± 0.93 %; p < 0.01). Both groups had a 100 % procedural success rate. The two groups showed comparable operation room stay times (RA vs. GA, 160 ± 6.96 min vs. 148 ± 5.90 min; p = 0.058). The mean rate of change in blood pressure, used as an index of hemodynamic stability, was significantly lower in the RA group (RA vs. GA, 19.0 ± 3.4 % vs. 35.5 ± 3.0 %; p < 0.01). No in-hospital deaths occurred in either group. One case of minor dissection occurred in the GA group (RA vs.GA, 0 % vs. 4.0 %, p = 0.378). The intensive care unit stay (RA vs. GA, 0.21 ± 0.11 days vs. 1.24 ± 0.10 days; p < 0.01) and hospital stay (RA vs. GA, 7.00 ± 1.73 days vs. 12.2 ± 1.44 days; p < 0.01) were significantly shorter in the RA group. Conclusions: MITS-TAVR under RA is safe and effective and might be a promising alternative approach. It could ensure intraoperative hemodynamic stability and shorten intensive care unit and hospital stays. Graphical abstract: Unlabelled Image Highlights: There were no vascular complications and disabling strokes the regional anesthesia (RA) group. Patent ipsilateral internal thoracic artery graft and dialysis fistula were not contraindications. Procedural and in-hospital outcomes were comparable between the two groups. Intraoperative hemodynamics were significantly stable in the RA group. Intensive care unit and hospital stay were significantly shortened in the RA group.