Preoperative evaluation of depth of invasion in oral tongue squamous cell carcinoma: A systematic review and meta-analysis. (January 2023)

• Record Type: Journal Article
• Authors: Voizard, Béatrice; Khoury, Michel; Saydy, Nadim; Nelson, Kristoff; Cardin, Guillaume B.; Létourneau-Guillon, Laurent; Filali-Mouhim, Abdelali; Christopoulos, Apostolos
• Is Part Of: Oral oncology. Volume 136(2023)
• Publication Date: 2023-01
• Subjects: Head and neck cancer -- Oral cancer -- Tongue neoplasms -- Squamous cell carcinoma -- Biopsy -- Diagnostic imaging -- Neoplasm staging -- Neoplasm invasiveness; DOI depth of invasion -- SCC squamous cell carcinoma -- OTSCC oral tongue squamous cell carcinoma -- rDOI depth of invasion measured on imaging -- pDOI depth of invasion measured on histopathology -- MRI magnetic resonance imaging -- CT computed tomography -- US ultrasound -- BM basement membrane -- TT tumour thickness -- rTT tumour thickness measured on imaging -- pTT tumour thickness measured on histopathology -- AJCC8 eighth edition of the American Joint Committee on Cancer -- SRMA systematic review and meta-analysis -- PRISMA Preferred Reporting items for systematic reviews and meta-analyses -- CI95% 95% confidence interval -- ICC inter-class coefficient -- UICC Union Internationale Contre le Cancer; Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2022.106273
• Languages: English
• ISSNs: 1368-8375

Abstract

Highlights: Depth of invasion is a prognostic factor in oral tongue squamous cell carcinoma. Magnetic resonance has good reliability to measure depth of invasion. Ultrasound is mainly studied to measure tumor thickness and not depth of invasion. Computed tomography has a lower reliability to measure depth of invasion. Abstract: The inclusion of depth of invasion (DOI) in the American Joint Committee on Cancer's staging system for oral cavity squamous cell carcinoma (SCC) has major clinical impacts. Recent studies have evaluated the reliability of imaging modalities and biopsy techniques to measure DOI preoperatively. The objective of this systematic review and meta-analysis was to comprehensively include all previously described methods to measure preoperative DOI in oral tongue SCC (OTSCC) and to compare their reliability. A systematic review was conducted on PubMed, Embase and Cochrane according to the PRISMA guidelines. Studies that evaluated the reliability of DOI measured on biopsy or imaging (rDOI) by comparing it to DOI on histopathology (pDOI) were included for extraction. A meta-analysis was conducted to obtain pooled correlation coefficients for each imaging modality. The pooled correlation coefficients between rDOI and pDOI were 0.86 (CI95% = [0.82–0.88]) and 0.80 (CI95% = [0.70–0.87]) for magnetic resonance imaging (MRI) studies and computed tomography (CT) studies, respectively. For ultrasound (US), the correlation coefficient could only be measured by including studies which measured not only DOI but also tumor thickness. It was 0.89 (CI95% = [0.82–0.94]). Overall, MRI is the better studied modality. It has a good reliability to measure preoperative rDOI in OTSCC. CT is less studied but appears to be less reliable. US cannot be compared to these imaging modality as it has been used more often to measure TT than DOI.