Cortico-cortical evoked potentials in response to varying stimulation intensity improves seizure localization. (January 2023)

• Record Type: Journal Article
• Authors: Hays, Mark A.; Smith, Rachel J.; Wang, Yujing; Coogan, Christopher; Sarma, Sridevi V.; Crone, Nathan E.; Kang, Joon Y.
• Is Part Of: Clinical neurophysiology. Volume 145(2023)
• Page Start: 119
• Page End: 128
• Publication Date: 2023-01
• Subjects: Cortico-cortical evoked potential -- Single pulse electrical stimulation -- intracranial EEG -- Effective connectivity -- Epileptogenic network -- Epilepsy; AUC area under the curve -- CCEP cortico-cortical evoked potential -- EEG electroencephalography -- EP early propagation -- IZ irritative zone -- nSOZ non-seizure onset zone -- RMS root mean square -- ROC receiver operating characteristic -- S-EEG stereo-electroencephalography -- SNR signal to noise ratio -- SOZ seizure onset zone -- SPES single pulse electrical stimulation; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2022.08.024
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Cortico-cortical evoked potential amplitude increases with current intensity with a greater effect in the seizure onset zone (SOZ). SOZ response distributions are maximized at lower currents, while those outside the SOZ gradually increase with current intensity. Responses to a range of current intensities provide better classification of the SOZ than responses to only one maximal intensity. Abstract: Objective: As single pulse electrical stimulation (SPES) is increasingly utilized to help localize the seizure onset zone (SOZ), it is important to understand how stimulation intensity can affect the ability to use cortico-cortical evoked potentials (CCEPs) to delineate epileptogenic regions. Methods: We studied 15 drug-resistant epilepsy patients undergoing intracranial EEG monitoring and SPES with titrations of stimulation intensity. The N1 amplitude and distribution of CCEPs elicited in the SOZ and non-seizure onset zone (nSOZ) were quantified at each intensity. The separability of the SOZ and nSOZ using N1 amplitudes was compared between models using responses to titrations, responses to one maximal intensity, or both. Results: At 2 mA and above, the increase in N1 amplitude with current intensity was greater for responses within the SOZ, and SOZ response distribution was maximized by 4–6 mA. Models incorporating titrations achieved better separability of SOZ and nSOZ compared to those using one maximal intensity. Conclusions: We demonstrated that differences in CCEP amplitude over a range of current intensities can improve discriminability of SOZ regions. Significance: This study provides insight into the underlying excitability of the SOZ and how differences in current-dependent amplitudes of CCEPs may be used to help localize epileptogenic sites.