Multi-year antimicrobial-resistance trends in urine Escherichia coli isolates from both community-based and hospital-based laboratories of an Australian local health district. (December 2022)

• Record Type: Journal Article
• Authors: Keighley, Caitlin; van Oijen, Antoine M.; Brentnall, Stuart J.; Sanderson-Smith, Martina; Newton, Peter; Miyakis, Spiros
• Is Part Of: Journal of global antimicrobial resistance. Volume 31(2022)
• Page Start: 386
• Page End: 390
• Publication Date: 2022-12
• Subjects: Antimicrobial resistance -- E. coli -- UTI -- Community -- Hospital; Drug resistance -- Periodicals; Drug resistance -- Periodicals; Drug resistance; Periodicals; 616.9041
• DOI: 10.1016/j.jgar.2022.11.008
• Languages: English
• ISSNs: 2213-7165

Abstract

Highlights: The incidence of AMR among urinary EC isolates is increasing in hospital and community settings. Although the rates of resistance were higher in hospital-based setting, the volume of resistant isolates was higher in the community-based laboratory There is a need for localised and regional surveillance of AMR focusing on both community and hospital settings. ABSTRACT: Objectives: Efforts to monitor and combat antimicrobial resistance (AMR) are typically focused on the hospital-based laboratory setting. The aim of this study was to longitudinally examine and compare trends in AMR among urine Escherichia coli isolates from a private community-based laboratory and a public hospital-based laboratory in an Australian local health district. Methods: A total of 108 262 urine E. coli isolates from a public hospital-based laboratory (N = 34 103) and a private community-based laboratory (N = 74 159) in a single health district between 2007–2019 were analysed. Linear regression was used to identify significance of change in AMR rates in both laboratories independently and detect any significant interaction of each setting in proportional change over the study period. Results: Similar AMR trends were detected among urinary E. coli isolates in private community-based laboratory and public hospital-based laboratory settings over 12 y. AMR rates were consistently higher in the public hospital-based setting. Ampicillin was the only antibiotic for which the E. coli resistance trend did not significantly change over the time period in either laboratory setting. All other antibiotics showed a significant increase in AMR rates over time in both settings. Conclusions: AMR rates in both the private community-based laboratory and public hospital-based laboratory settings increased over time and were consistently higher in the public hospital-based laboratory setting. Since private laboratories handle the vast majority of pathology volumes in community outpatient settings in Australia, interventions incorporating the community-based laboratory setting are critical to addressing AMR in the community.