Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer. (October 2022)

• Record Type: Journal Article
• Authors: Seol, Seung Won; Lee, Brian H.; Sita, Timothy L.; Devineni, Jay Ram; Kruser, Tim J.; Sachdev, Sean; Gentile, Michelle; Helenowski, Irene; Mittal, Bharat B.
• Is Part Of: Physics and imaging in radiation oncology. Volume 24(2022)
• Page Start: 71
• Page End: 75
• Publication Date: 2022-10
• Subjects: Oropharyngeal -- Hippocampus -- Hippocampus-sparing -- IMRT -- Plan optimization; Radiotherapy -- Periodicals; Radiation dosimetry -- Periodicals; Cancer -- Imaging -- Periodicals; Oncology -- Periodicals; 615.842
• DOI: 10.1016/j.phro.2022.09.008
• Languages: English
• ISSNs: 2405-6316

Abstract

Abstract: This study aimed to assess the incidental radiation exposure of the hippocampus (HC) in locoregionally-advanced oropharyngeal cancer patients undergoing volumetric modulated arc therapy and the feasibility of HC-sparing plan optimization. The initial plans were generated without dose-volume constraints to the HC and were compared with the HC-sparing plans. The incidental Dmean _median doses to the bilateral, ipsilateral and contralateral HC were 2.9, 3.1, and 2.5 Gy in the initial plans and 1.4, 1.6, and 1.3 Gy with HC-sparing. It was feasible to reduce the HC dose with HC-sparing plan optimization without compromising target coverage and/or dose constraints to other OARs.