Global influenza vaccination rates and factors associated with influenza vaccination. (December 2022)

• Record Type: Journal Article
• Authors: Chen, Can; Liu, Xiaoxiao; Yan, Danying; Zhou, Yuqing; Ding, Cheng; Chen, Lu; Lan, Lei; Huang, Chenyang; Jiang, Daixi; Zhang, Xiaobao; Guan, Zhou; Fu, Xiaofang; Du, Yuxia; Lin, Yushi; Zhu, Changtai; Wu, Jie; Li, Lanjuan; Yang, Shigui
• Is Part Of: International journal of infectious diseases. Volume 125(2022)
• Page Start: 153
• Page End: 163
• Publication Date: 2022-12
• Subjects: Influenza vaccination rates -- Influencing factors -- Meta-analysis -- Meta-regression; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2022.10.038
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: The global influenza vaccination rates (IVRs) were overall low, especially in the general population. Compared to middle-income, IVRs were higher in high-income countries/regions. Compared to the other period, IVRs increased during the COVID-19 pandemic. Free vaccination policies was the positive factor for the higher IVR. Abstract: Objectives: Influenza vaccination is an effective method for preventing influenza virus infection. Herein, we performed a meta-analysis to quantify global influenza vaccination rates (IVRs) and the factors influencing its uptake in the general population, individuals with chronic diseases, pregnant women, and healthcare workers. Methods: Related articles were obtained from online databases and screened according to the inclusion criteria. The pooled IVRs were calculated using the random effects model. Subgroup analyses and multivariate meta-regression were performed to determine the factors associated with influenza vaccine uptake. Results: We included 522 studies from 68 countries/regions. Most studies were conducted in the European region (247 studies), followed by the Western Pacific (135 studies) and American regions (100 studies). The IVRs with 95% confidence intervals (CIs) in the general population were lower (24.96%, 23.45%-26.50%) than in individuals with chronic diseases (41.65%, 40.08%-43.23%), healthcare workers (36.57%, 33.74%-39.44%), and pregnant women (25.92%, 23.18%-28.75%). The IVRs in high-income countries/regions were significantly higher than that in middle-income countries/regions. A free national or regional vaccination policy, perception of influenza vaccine efficacy and disease severity, a recommendation from healthcare workers, and having a history of influenza vaccination were positive factors for vaccine uptake ( P <0.01). Conclusion: Overall, global IVRs were low, especially in the general population. The studies on the IVRs, especially for priority populations, should be strengthened in Eastern Mediterranean, South-East Asian, and African regions. Free vaccination policies and the dissemination of continuous awareness campaigns are effective measures to enhance vaccination uptake.