Treatment of major depressive disorder (MDD) or dysthymic disorder (DD) in spinal cord injury (SCI) patients: a protocol for a systematic review and network meta-analysis. Issue 12 (14th December 2022)

• Record Type: Journal Article
• Authors: Han, Ji Min; Choi, Won Seuk; Choi, Hyun; Jang, Bo-Hyoung; Kim, Hyun-Jin; Son, Chi Hyoung; Park, Ji Young; Kim, Ye Soon; Jang, Hyo Jin; Kim, Jung Hwan
• Is Part Of: BMJ open. Volume 12:Issue 12(2022)
• Publication Date: 2022-12-14
• Subjects: Depression & mood disorders -- PSYCHIATRY -- CLINICAL PHARMACOLOGY -- MENTAL HEALTH; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2021-055800
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Introduction: Although various treatments exist for depression in patients with spinal cord injury (SCI), the comparative effects and relationships between these treatments have not been clearly presented. This study aims to present comprehensive evidence for the treatment of major depressive disorder or dysthymic disorder in patients with SCI by comparing the therapeutic and adverse effects of pharmacological and non-pharmacological treatments through a systematic review and network meta-analysis. Methods and analysis: We will search for studies in five databases (Medline, Central, Embase, PsycINFO and CHINAL) as well as clinical trial registries (US National Institutes of Health Ongoing Trials Register ClinicalTrials.gov (www.clinicaltrials.gov ), WHO International Clinical Trials Registry Platform (www.who.int/trialsearch )) and grey literature (Google Scholar). The references of the included studies, previous systematic reviews and meta-analyses will be reviewed. Study selection, data extraction and quality and risk of bias assessments will be independently performed by two authors (JMH and WSC), and disagreements will be resolved by discussion with JHK. Moreover, a Bayesian network meta-analysis will be performed using R software. Ethics and dissemination: Our systematic review and network meta-analysis will be performed based on existing studies; thus, we did not seek ethical approval. Our results will be published in a peer-reviewed journal and presented at both domestic and international conferences.