Association of anti-tuberculosis drug concentrations in hair and treatment outcomes in MDR- and XDR-TB. Issue 2 (26th April 2019)

• Record Type: Journal Article
• Authors: Metcalfe, John; Bacchetti, Peter; Gerona, Roy; Esmail, Ali; Dheda, Keertan; Gandhi, Monica
• Is Part Of: ERJ open research. Volume 5:Issue 2(2019)
• Publication Date: 2019-04-26
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; Respiration; Respiratory organs -- Diseases; Respiratory organs -- Diseases -- Treatment; Respiratory Tract Diseases; Electronic journals; Fulltext; Internet Resources; Periodicals; Periodical; 616.2005
• DOI: 10.1183/23120541.00046-2019
• Languages: English
• ISSNs: 2312-0541

Abstract

Anti-tuberculosis drug concentrations in hair, a non-biohazardous and noninvasively collected biomatrix, predict extensively drug-resistant-TB clinical outcomes in a high-burden setting. http://ow.ly/80xi30o8qSa Therapeutic drug monitoring for drug-resistant tuberculosis (TB) is likely to improve treatment outcomes. While assessments of plasma drug levels can explain pharmacokinetic variability among trial participants, these measures require phlebotomy and a cold chain, and are generally not repeated frequently enough to characterise drug exposure over time. Using a novel multi-analyte assay, we found evidence that higher anti-TB drug concentrations in hair, a non-biohazardous and noninvasively collected biomatrix, predict extensively-drug resistant-TB clinical outcomes in a high-burden setting.