Gaps, Controversies, and Proposed Roadmap for Research in Poststroke Movement Disorders. Issue 10 (14th September 2022)

• Record Type: Journal Article
• Authors: Pandey, Sanjay; Joutsa, Juho; Mehanna, Raja; Shukla, Aparna Wagle; Rodriguez‐Porcel, Federico; Espay, Alberto J.
• Is Part Of: Movement disorders. Volume 37:Issue 10(2022)
• Page Start: 1996
• Page End: 2007
• Publication Date: 2022-09-14
• Subjects: stroke -- movement disorders -- dystonia -- neuroimaging; Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.29218
• Languages: English
• ISSNs: 0885-3185

Abstract

ABSTRACT: Poststroke movement disorders (PSMDs) are a common cause of secondary movement disorders. Although prior studies have highlighted the clinical spectrum and phenomenology of PSMDs, there are many knowledge gaps worth addressing. Some of the most important include lack of clinical definitions, variable stroke symptom latencies, and lack of biomarkers for vulnerability for or resilience against developing PSMDs. Collectively, the association between stroke localization and phenomenology is less than 30%, and the long‐term clinical prognosis and treatment responses are highly variable. After summarizing the accumulated evidence regarding the phenomenology, pathophysiology, neuroimaging, and treatment of PSMDs, highlighting the many gaps and controversies including diagnostic challenges, we propose a roadmap for future research to fill these gaps and resolve the related controversies. More research is warranted concerning the phenomenology, classification, diagnostic criteria, and pathophysiology of PSMDs. Further, there is an urgent need for treatment guidelines for the management of PSMDs. © 2022 International Parkinson and Movement Disorder Society.