Molecular testing in cytology. Issue 1 (11th November 2022)

• Record Type: Journal Article
• Authors: Schmitt, Fernando; Yang, Zhongbo; Esebua, Magda
• Other Names: Schmitt Fernando guestEditor.; Yang Zhongbo guestEditor.; Esebua Magda guestEditor.
• Is Part Of: Diagnostic cytopathology. Volume 51:Issue 1(2023)
• Page Start: 3
• Page End: 4
• Publication Date: 2022-11-11
• Subjects: cytology samples -- molecular testing; Cytodiagnosis -- Periodicals; Pathology, Cellular -- Periodicals; Cytology -- Periodicals; 616.07582
• DOI: 10.1002/dc.25071
• Languages: English
• ISSNs: 8755-1039

Abstract

Abstract: In the era of personalized medicine, molecular testing plays a critical role in patient care. The rapid advance of molecular techniques, especially next‐generation sequencing, makes molecular diagnosis feasible in daily practice. Molecular testing can be used as a valuable ancillary test to increase diagnostic sensitivity and specificity, especially in small biopsy or cytology samples. In addition, molecular testing plays an important role in selecting patients for appropriate treatment by detecting therapeutic and predictive biomarkers in tissue or cytology samples. Molecular studies can be applied in all cytology samples, sometimes with better results than histology. As molecular testing has become essential for patient care and is often requested to be performed in cytology samples, it is critical for cytopathologists to understand the basics of molecular diagnostic methods, indications for molecular testing, and how to best utilize different cytologic samples for this purpose. In this special issue, experts in various areas of cytopathology and molecular pathology review the literature and discuss the basics of molecular techniques and the application of molecular testing in various types of cytology samples. It is our hope that after reading the articles in this special issue, the readers can know better about the possibilities of molecular cytology, a very exciting field of pathology.