Tissue adaptation of regulatory T cells in adipose tissue. Issue 12 (24th November 2022)

• Record Type: Journal Article
• Authors: Yu, Yimeng; Bai, Hongyu; Wu, Fenglin; Chen, Jieqiong; Li, Bin; Li, Yangyang
• Is Part Of: European journal of immunology. Volume 52:Issue 12(2022)
• Page Start: 1898
• Page End: 1908
• Publication Date: 2022-11-24
• Subjects: adipose tissue -- Foxp3 -- metabolic disease -- obesity -- regulatory T cell; Immunology -- Periodicals; 616.079
• DOI: 10.1002/eji.202149527
• Languages: English
• ISSNs: 0014-2980

Abstract

Abstract: Foxp3 + regulatory T (Treg) cells critically suppress over‐activated immune responses and therefore maintain immune homeostasis. Adipose tissue‐resident Treg (AT Treg) cells are known for modulating immunity and metabolism in adipose tissue microenvironment through various physiological signals, as well as their heterogeneous subsets, which potentially play disparate roles in aging and obesity. Recent single‐cell studies of Treg cells have revealed specialized trajectories of their tissue adaptation and development in lymphoid tissues and at barrier sites. Here, we reviewed a T Cell Receptor (TCR)‐primed environmental cue‐boosted model of adipose Treg cells' tissue adaptation, especially in response to IL‐33, IFN‐α, insulin, and androgen signals, which trigger sophisticated transcriptional cascades and ultimately establish unique transcriptional modules in adipose Treg cell subsets. In addition, we further discuss potential therapeutic strategies against aging and obesity by blocking detrimental environmental cues, strengthening the functions of specific AT Treg subsets and modifying the communications between AT Treg subsets and adipocytes. Abstract : Adipose Regulatory T (Treg) cells express the key transcription factors Foxp3 and PPARγ, have immune supressive activity and critically maintain immune homeostasis and metabolic health. Environmental cues, including antigens, IL‐33, IFN‐α and insulin, fine‐tune Treg cells to express unique gene modules, leading to tissue adaptation and functional diversity of adipose tissue‐resident Treg cells in the context of obesity, aging and cold exposure.