Plasminogen-derived peptide promotes adipogenic differentiation of preadipocytes in vitro and in vivo. (31st December 2022)

• Record Type: Journal Article
• Authors: Yang, Hea Jung; Kim, Jong-Ho; Shim, Jung Hee; Heo, Chan Yeong
• Is Part Of: Adipocyte. Volume 11:Number 1(2022)
• Page Start: 643
• Page End: 652
• Publication Date: 2022-12-31
• Subjects: Adipose-derived stem cell (ADSC) -- breast cancer -- differentiation -- peptide -- plasminogen (PLG); Fat cells -- Periodicals; Adipocytes -- Periodicals; 611.018276
• DOI: 10.1080/21623945.2022.2149121
• Languages: English
• ISSNs: 2162-3945

Abstract

ABSTRACT: Soft tissue defects caused by adipose tissue loss can result in various conditions such as lipodystrophy in congenital diseases, trauma secondary to ageing, and mastectomy in breast cancer; fat grafting is commonly performed to restore these defects. Although various enrichment strategies have been studied, novel therapeutics that are cost-effective, safe, technologically easy to manufacture, and minimally invasive are required. In this study, we identified a novel peptide derived from plasminogen, named plasminogen-derived peptide-1 (PLP-1), which showed adipogenic differentiation potential and led to an increase in the expression levels of adiponectin, C1Q and collagen domain containing protein, fatty acid-binding protein 4, and CCAAT/enhancer-binding protein-alpha. In vivo experiments confirmed an increase in the rate of adipocyte differentiation and the expression levels of CD31 in the PLP-1-treated mice groups. These results suggested that PLP-1 plays an important role in promoting the differentiation of preadipocytes and may be useful for developing therapeutic approaches to treat adipose tissue defects.