3D-printed microfluidic droplet generation systems for drug delivery applications. (2022)

• Record Type: Journal Article
• Authors: Noroozi, Reza; Mashhadi Kashtiban, Mohsen; Taghvaei, Hadi; Zolfagharian, Ali; Bodaghi, Mahdi
• Is Part Of: Materials today. Volume 70(2022)
• Page Start: 443
• Page End: 446
• Publication Date: 2022
• Subjects: 3D printing -- Drug delivery -- Microfluidic -- Tissue engineering -- PCL; PCL Polycaprolactone -- SEM Scanning electron microscope -- FDM Fused Deposition Modeling -- SLA Stereolithography -- PDMS Polydimethylsiloxane -- AM Additive manufacturing -- PLA Polylactic acid -- PVA Polyvinyl alcohol; Materials science -- Congresses -- Periodicals; 620.1
• DOI: 10.1016/j.matpr.2022.09.363
• Languages: English
• ISSNs: 2214-7853

Abstract

Highlights: 3D Printing a microfluidic-based drug delivery system. Implementing SLS and FDM to generate polycaprolactone (PCL) droplets loaded with the drug. Generating highly stable particles with higher encapsulation efficiency. SEM and microscopic images show the effectiveness of fabricated chips in generating PCL droplets. Abstract: Drug delivery systems are advanced methods that aim to deliver a targeted drug to a specific location or release it at a controlled rate. Many methods have been proposed for drug delivery systems, among which microfluidic systems present unique advantages. In contrast to bulk methods, in this work, by considering the unique capacity of microfluidic-based drug delivery systems, including controllability of fabricated chip geometry and flow rate of multiphase fluid, highly stable particles with higher encapsulation efficiency can be generated. Employing additive manufacturing in biomedical applications has enabled researchers to propose novel and accurate microfluidic systems. In this paper, by employing stereolithography (SLA) and fused deposition modeling (FDM) 3D printing, a microfluidic-based drug delivery system for generating polycaprolactone (PCL) droplets loaded with dexamethasone drug is fabricated. Scanning electron microscope (SEM) images and microscopic images show the effectiveness of this method in generating such droplets.