N-formylation of isoquinoline derivatives with CO2 and H2 over a heterogeneous Ru/ZIF-8 catalyst. Issue 1 (31st December 2022)

• Record Type: Journal Article
• Authors: He, Zhen-Hong; Wei, Yuan-Yuan; Li, Na; Sun, Yong-Chang; Yang, Shao-Yan; Wang, Kuan; Wang, Weitao; Ma, Xiaoxue; Liu, Zhao-Tie
• Is Part Of: Journal of experimental nanoscience. Volume 17:Issue 1(2022)
• Page Start: 61
• Page End: 74
• Publication Date: 2022-12-31
• Subjects: N-formylation -- isoquinoline derivatives -- CO2 -- Ru catalyst -- ZIF-8; Nanoscience -- Periodicals; Nanotechnology -- Periodicals; Nanomedicine -- Periodicals; Nanotechnology -- Periodicals; 620.5
• DOI: 10.1080/17458080.2022.2025781
• Languages: English
• ISSNs: 1745-8080

Abstract

Abstract: Chemical utilization of CO2 is one of the fundamental strategies to synthesize value-added chemicals and reduce the CO2 emission. N- formyl-1, 2, 3, 4-tetrahydroisoquinoline derivatives (FTHIQs) are important chemicals for the synthesis of medical intermediates and alkaloids . N -formylation of isoquinoline derivatives (IQs) with CO2 is an ideal protocol to synthesize the FTHIQs and utilize the CO2 source. In the present work, we prepared a heterogeneous Ru/ZIF-8 catalyst with a Ru loading of 2 wt% by a simple impregnation method and assessed its performances in the N -formylation of IQs and CO2 with H2 . The Ru/ZIF-8 catalyst offered high IQ conversion of 98% and FTHIQ selectivity of 93% in the reaction under relatively mild conditions (150 °C, 2 MPa CO2, and 6 MPa H2 ). The catalyst possessed good universality and reusability, showing a potential in wide application of N -formylation of highly unsaturated nitrogen-containing isoquinolines.