Supramolecular catalytic nanomedicines based on coordination self-assembly of amino acids for cascade-activated and -amplified synergetic cancer therapy. Issue 47 (30th November 2022)

• Record Type: Journal Article
• Authors: Song, Enhui; Wu, Qiong; Gao, Ren; Lan, Xiaopeng; Zhang, Yanhui; Geng, Hao; Liu, Chunlei; Xu, Feijie; Li, Yongxin; Liu, Chunzhao
• Is Part Of: Journal of materials chemistry. Volume 10:Issue 47(2022)
• Page Start: 9838
• Page End: 9847
• Publication Date: 2022-11-30
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d2tb02326a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : An amino acid based- supramolecular nanomedicine is constructed based on multicomponent coordination self-assembly for tumor cascade- activated and -amplified synergetic catalytic-chemotherapy, which achieved efficient tumor growth suppression. Abstract : Simple biomolecule-based supramolecular nanomedicines hold great promise in cancer therapy, but their clinical translation is greatly hindered by low tumor-specificity and unsatisfactory antitumor performance. Herein, we developed an amino acid basedsupramolecular nanomedicine that could be co-activated by multiple stimuli in tumor tissue to trigger cascade catalytic reactions in situ for synergetic therapy. The supramolecular nanomedicine was developed based on a combination of coordination and hydrophobic noncovalent interactions among amphiphilic amino acids, glucose oxidase (GOx), copper ions, as well as doxorubicin (DOX)–camptothecin (CPT) prodrugs. The cascade reactions including the catalytic oxidation of glucose to generate H2 O2, GSH reducing Cu 2+ to Cu +, a Fenton-like reaction between H2 O2 and Cu + to produce hydroxyl radicals (˙OH), and ˙OH-triggered rapid release of dual parent drugs were specifically activated in tumor cells. With these cascade reactions, the catalytic-chemo synergetic therapy was realized for high-efficiency tumor suppression.