Multifunctional theragnostic ultrasmall gold nanodot-encapsuled perfluorocarbon nanodroplets for laser-focused ultrasound sequence irradiation (LFSI)-based enhanced tumor ablation. Issue 47 (25th November 2022)

• Record Type: Journal Article
• Authors: Xu, Menghan; Long, Wei; Ling, Xiang; Hu, Xiongwei; Hong, Hao; Peng, Yayun; Cai, Ting
• Is Part Of: Journal of materials chemistry. Volume 10:Issue 47(2022)
• Page Start: 9816
• Page End: 9829
• Publication Date: 2022-11-25
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d2tb01775j
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Multifunctional ultrasmall Au nanodots-loaded perfluorocarbon nanodroplets (Au-PFCnDs) were prepared for enhanced tumor ablation therapy via a facile laser-focused ultrasound sequence irradiation (LFSI) method. Abstract : Despite the substantial potential of focused ultrasound therapy, its efficacy in cancer therapy has been limited due to the high cavitation threshold and safety concerns regarding the use of high-intensity energy pulses. Here, ultrasmall Au nanodot-loaded PEG-modified perfluorocarbon nanodroplets (Au-PFCnDs) were prepared and used as a therapeutic enhancer. A LFSI method was designed to achieve enhanced tumor ablation at a mild focused ultrasound (FUS) energy pulse with the assistance of the instinct photothermal effect of intratumor-permeable ultrasmall Au nanodots under 808 nm NIR laser irradiation. In addition to their therapeutic function, Au-PFCnDs can also generate multimodal images to provide information for tumor surveillance and treatment guidance. The experimental results also showed that the cRGD-targeted Au-PFCnDs could be more efficiently delivered into the tumor and selectively destroy tumors with no observable side effects on normal tissue under LFSI treatment.