Incorporating zeolitic-imidazolate framework-8 nanoparticles into kidney scaffolds: a first step towards innovative renal therapies. Issue 47 (24th November 2022)

• Record Type: Journal Article
• Authors: Guerrero, Fátima; Pulido, Victoria; Hamad, Said; Aljama, Pedro; Martín-Malo, Alejandro; Carrillo-Carrión, Carolina
• Is Part Of: Nanoscale. Volume 14:Issue 47(2022)
• Page Start: 17543
• Page End: 17549
• Publication Date: 2022-11-24
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d2nr04246k
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : We demonstrate the successful immobilization of polymer-stabilized ZIF-8 nanoparticles within a kidney scaffold, endowing it with a high adsorption capacity to remove uremic toxins (mainly hydrophobic ones) under flow conditions. Abstract : We demonstrate for the first time the potential of zeolitic-imidazolate framework-8 nanoparticles to be incorporated within a renal scaffold while retaining their ability to remove uremic toxins (mainly hydrophobic toxins like p -cresol) under flow conditions. This work may pave the way for the future development of novel adsorbents for dialysis and/or artificial kidneys.