Longitudinal Assessment of Bile Duct Loss in Primary Biliary Cholangitis. (1st December 2022)

• Record Type: Journal Article
• Authors: Hercun, Julian; Noureddin, Mazen; Noureddin, Nabil; Eccleston, Jason; Woolridge, Daniel; Liang, T. Jake; Tana, Michele; Kleiner, David E.; Rodriguez, Gracia Viana; Koh, Christopher; Hoofnagle, Jay H.; Heller, Theo
• Is Part Of: American journal of gastroenterology. Volume 117:Number 12(2022)
• Page Start: 2075
• Page End: 2078
• Publication Date: 2022-12-01
• Subjects: Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Gastrointestinal Diseases -- Periodicals; Electronic journals; Periodicals; 616.33
• DOI: 10.14309/ajg.0000000000001985
• Languages: English
• ISSNs: 0002-9270

Abstract

Abstract : INTRODUCTION: Bile duct involvement is a key finding of primary biliary cholangitis (PBC). The aim of this study was to evaluate baseline ductopenia and disease progression. METHODS: Retrospective longitudinal histological follow-up of treatment-naive patients with PBC. RESULTS: Eighty-three patients were included, with ductopenia correlated to fibrosis stage at baseline. The cumulative incidence of severe ductopenia remained stable after 5 years, whereas fibrosis continually increased over time. Baseline AST-to-Platelet Ratio Index and elevated alkaline phosphatase >2 times the normal with abnormal bilirubin were associated with ductopenia progression. DISCUSSION: Bile duct injury does not seem to follow the same course as fibrosis in PBC.