The perivascular niche of endometrial mesenchymal stromal/stem-like cells. Issue 4 (29th November 2022)

• Record Type: Journal Article
• Authors: Chan, Rachel W. S.; Li, Tian-Qi; Zhang, Si-Si; Fang, Yuan; Xu, Jing-Wen
• Is Part Of: Reproductive and developmental medicine. Volume 6:Issue 4(2022)
• Page Start: 208
• Page End: 214
• Publication Date: 2022-11-29
• Subjects: Endometrium -- Regeneration -- Stem/progenitor cells -- Stem cell niche; Reproductive Physiological Phenomena; Reproductive Techniques; Reproductive Medicine; Developmental Biology; Reproductive health; Developmental biology; Electronic journals; Periodical; Periodicals; 612.6
• DOI: 10.1097/RD9.0000000000000038
• Languages: English
• ISSNs: 2096-2924

Abstract

Abstract : Human endometrium is a unique adult tissue that undergoes cyclical shedding, repair, and regeneration during a woman's reproductive life. Over the past 2 decades, tremendous progress has been made towards the identification and characterization of endometrial stromal stem/progenitor cells . The substantial regeneration of vascularized stroma in the endometrium during the proliferative stages of each menstrual cycle is likely to be mediated by endometrial mesenchymal stromal/stem cells. This review focuses on the perivascular niche for CD140b + CD146 + pericytes and SUSD2 + perivascular cells. The identity, characteristics, and underlying mechanisms of uterine regeneration are also discussed.