Acupuncture for Crohn's disease: protocol for a systematic review and meta-analysis of randomized clinical trials. Issue 48 (2nd December 2022)

• Record Type: Journal Article
• Authors: Cao, Jiazhen; Yu, Qianhui; Sun, Mengmeng; He, Min; Liu, Renming; Liu, Wu; Wang, Fuchun; Li, Tie
• Is Part Of: Medicine. Volume 101:Issue 48(2022)
• Page Start: e32163
• Publication Date: 2022-12-02
• Subjects: acupuncture -- Crohn's disease -- protocol -- systematic evaluation; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000032163
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Background: Crohn's disease (CD) is a chronic recurrent gastrointestinal disorder with a high incidence of inflammation due to intestinal inflammation. Acupuncture is commonly used as an alternative therapy for patients with CD. The aim of this study was to design a systematic review and meta-analysis protocol, to provide guidance for the establishment of systematic evaluation and meta-analysis on the efficacy and safety of acupuncture on CD. Methods: We will search PubMed, the Cochrane Library, Embase, Web of Science, and 4 Chinese databases: China National Knowledge Infrastructure (CNKI), Wanfang database, VIP database, and Chinese Biomedical Database to obtain randomized controlled trials of CD treated with acupuncture from inception to November 5, 2022. Primary outcome include CD symptoms severity and clinical efficacy, secondary outcome indicators include laboratory indicators or inflammatory markers, severity of endoscopic lesions, quality of life, and safety outcomes. We will analyze the data using RevMan V.5.4 software. Two reviewers will assess the risk of bias and study quality by the Cochrane Collaboration Risk of Bias Tool and GRADE methods, respectively. Results: This systematic review and meta-analysis protocol will analyze the efficacy, symptom improvement, quality of life, and safety of acupuncture therapy for CD. Conclusion: This protocol outlines the planned scope and methodology of a forthcoming systematic review and meta-analysis to provide guidelines for a rigorous assessment of the efficacy and safety of acupuncture for the treatment of CD.