Acute promyelocytic leukemia in a long-standing HIV-positive patient: Case report and literature review. (2022)

• Record Type: Journal Article
• Authors: Mendes-de-Almeida, Daniela P.; Fernandez, Teresa de Souza; Lovatel, Viviane Lamim; da Rocha, Moises Martins; Gomes, Bernadete Evangelho; Monte-Mór, Bárbara C.R.; Vianna, Danielle Tavares; Alcoforado, Marília T.G.; Kronemberg, João Marcello P.B.; Cardoso, João Pedro S.C.; Oliveira, Vanessa da Gama; Bokel, Joanna; Vizzoni, Alexandre G.; Nunes, Estevão Portela; Grinsztejn, Beatriz
• Is Part Of: Leukemia research reports. Volume 18(2022)
• Publication Date: 2022
• Subjects: Acute myeloid leukemia -- HIV infection -- AIDS -- Antiretroviral therapy -- Acute promyelocytic leukemia; Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2022.100339
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: The use of antiretroviral therapy has drastically improved the life quality and prognosis of people living with the human immunodeficiency virus (HIV). The risk of acute myeloid leukemia (AML) currently does not appear to be significantly increased compared to the general population. Acute promyelocytic leukemia (APL), infrequent in people with HIV, is a distinct subtype of AML with unique molecular pathogenesis, clinical manifestations, and treatment. Herein we describe a fatal case of APL hypogranular variant in an HIV-positive patient presenting with hyperleukocytosis. Also, we conducted a literature review of the ten cases reported so far.