The knowns and many unknowns of CNS immunity in teleost fish. Issue 131 (December 2022)

• Record Type: Journal Article
• Authors: Mani, Amir; Salinas, Irene
• Is Part Of: Fish & shellfish immunology. Issue 131(2022)
• Page Start: 431
• Page End: 440
• Publication Date: 2022-12
• Subjects: Teleost -- Brain -- Immunity -- Infection -- Neuroimmunology; Fishes -- Immunology -- Periodicals; Shellfish -- Immunology -- Periodicals; Poissons -- Immunologie -- Périodiques; Crustacés -- Immunologie -- Périodiques; 571.9617
• DOI: 10.1016/j.fsi.2022.10.013
• Languages: English
• ISSNs: 1050-4648

Abstract

Abstract: Many disease agents infect the central nervous system (CNS) of teleost fish causing severe losses for the fish farming sector. Yet, neurotropic fish pathogens remain poorly documented and immune responses in the teleost CNS essentially unknown. Previously thought to be devoid of an immune system, the mammalian CNS is now recognized to be protected from infection by diverse immune cells that mostly reside in the meningeal lymphatic system. Here we review the current body of work pertaining immune responses in the teleost CNS to infection. We identify important knowledge gaps with regards to CNS immunity in fish and make recommendations for rigorous experimentation and reporting in manuscripts so that fish immunologists can advance this burgeoning field. Highlights: We provide an overview of the teleost brain anatomy. We summarize the literature pertaining immune responses in the teleost brain to infection. We identify knowledge gaps in the field of brain immunity in teleosts. We suggest experimental and reporting standards when investigating teleost brain immunity.